grant
Clostridioides difficile Zinc-binding PBPs as anti-sporulation targets
Organization UNIVERSITY OF SOUTH FLORIDALocation TAMPA, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025Active SitesAddressAnimal ModelAnimal Models and Related StudiesAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAssayBacteriaBeta-Lactam resistantBindingBioassayBiochemicalBiochemistryBiologicalBiological AssayBiological ChemistryBiologyC diffC difficileC. diffC. difficileCarboxypeptidaseCell SurvivalCell ViabilityCell WallCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Cephalosporin ResistanceCephalosporinsCephamycinsChemicalsClassificationClinicClinicalClostridioides difficileClostridium difficileComplexCrystallographiesCrystallographyCutting edge antibioticsDevelopmentDietary ZincDockingDrugsE coliE. coliEnvironmentEnzyme GeneEnzymesEscherichia coliEsteroproteasesFlagylFrequenciesFutureGI microbiotaGastrointestinal microbiotaGeneralized GrowthGenomeGoalsGram-Positive BacteriaGrowthHospital InfectionsHospital acquired infectionIn VitroInfectionIntestinal DiseasesIntestinal DisorderInvestigationInvestigatorsIonsKnock-outKnockoutKnowledgeLactam AntibioticsLactamsLifeLife CycleLife Cycle StagesLigand BindingMedicationMedicinal ChemistryMetronidazoleMiscellaneous AntibioticMolecularMolecular InteractionMonobactam AntibioticsMonobactamsMonocyclic beta-LactamsMureinNosocomial InfectionsP aeruginosaP. aeruginosaPathogenesisPatientsPenicillin Binding Protein 1Penicillin-Binding ProteinsPeptidasesPeptide HydrolasesPeptidesPeptidoglycanPeptidyl TransferasesPeptidyl TranslocasesPeptidyltransferasePharmaceutic ChemistryPharmaceutical ChemistryPharmaceutical PreparationsPhysiologyPlayPredispositionProductionPropertyProtease GeneProteasesProteinasesProteinsProteolytic EnzymesPseudomonas aeruginosaPseudomonas pyocyaneaPublishingReagentRecurrenceRecurrentReproduction sporesResearch PersonnelResearchersResistanceResistance profileResistance to antibioticsResistant profileResistant to antibioticsRisk FactorsRoleS aureusS. aureusSatricSeriesSiteSporesStaph aureusStaphylococcus aureusStructureSubgroupSusceptibilitySystematicsTimeTissue GrowthToxinTransmissionTranspeptidasesUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionVancomycinZincZn elementantibiotic drug resistanceantibiotic resistantantibiotic toleranceb lactam resistanceb-lactam resistantbeta-Lactam Resistancebiologiccephalosporin resistantcrosslinkdesigndesigningdevelopmentaldrug discoverydrug/agententeric microbial communityenteric microbiotaexperimentexperimental researchexperimental studyexperimentsfuture antibioticsgastrointestinal microbial floragut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorain vivoinfection rateinfection recurrenceinhibitorinsightinstitutional infectionintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine diseaseintestine disorderknock-downknockdownknockout genelife coursemodel of animalmodel organismmouse modelmurine modelnew combination therapiesnew generation antibioticsnext generation antibioticsnextgen antibioticnovelontogenyoverexpressoverexpressionpathogenpreventpreventingprotein functionrate of infectionrecurrent infectionrecurring infectionresilienceresilientresistance against beta lactamsresistance to b lactamresistance to beta-lactamresistance to cephalosporinresistance to β-Lactamresistantresistant to b lactamresistant to beta-lactamresistant to cephalosporinresistant to β-Lactamsimulationsocial roletherapeutic agent developmenttherapeutic developmenttolerance to antibioticstolerate antibioticstransmission processurgent antibiotic resistanceurgent antibiotic resistantβ-Lactam Resistanceβ-Lactam resistant
Description preview
Abstract
Clostridioides difficile is the leading cause of nosocomial infection. The use of b-lactam antibiotics, especially
cephalosporins, is a major risk factor for infection, but high dietary zinc concentrations have also been shown to
increase infection rates. Current treatments of C. difficile infection (CDI) are plagued by high recurrence…
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