grant
Clonal Hematopoiesis Aging Resiliency Mechanisms
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 15 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025100+ years oldAberrant ChromosomeAddressAffectAgeAgingAllelic LossAmentiaApoplexyAscorbic AcidAssayBioassayBiologic ModelsBiological AssayBiological ModelsBirthBloodBlood FractioningBlood PlasmaBlood Precursor CellBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesBrain Vascular AccidentCancersCardiovascular DiseasesCell BodyCellsCentenarianCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityClonal ExpansionClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionCollectionComputing MethodologiesCritical PathsCritical PathwaysCytogenetic AberrationsCytogenetic AbnormalitiesDNADNA mutationDataData SetDementiaDeoxyribonucleic AcidDevelopmentDiseaseDisease OutcomeDisorderDrugsEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchExperimental HematologyGene variantGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenomic approachGenomicsGerm-Line MutationGrowthHealthHematopoietic Progenitor CellsHematopoietic stem cellsHepatic DisorderHereditaryHereditary MutationHumanIn VitroIncidenceIndividualInfectionInheritedKidney DiseasesKnowledgeLinkLiver diseasesLoss of HeterozygosityMalignant NeoplasmsMalignant TumorMedicationModel SystemModelingModern ManMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMosaicismMutationNHLBINational Heart, Lung, and Blood InstituteNational Institutes of HealthNatureNephropathyNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersParticipantParturitionPersonsPharmaceutical PreparationsPhenotypePlasmaPlasma SerumPoint MutationPopulationPredictive FactorPreventative interventionProcessProteinsProteomicsRenal DiseaseResearchResistanceRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderReticuloendothelial System, Serum, PlasmaRiskRoleSamplingScientific Advances and AccomplishmentsSomatic MutationStrokeSurvey InstrumentSurveysSystemTOPMedTestingTimeTissue GrowthTissuesTrans-Omics for Precision MedicineUnited States National Institutes of HealthVIT CVitamin CVitaminsWorkadult youthadverse consequenceadverse outcomeage related pathwaysaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging associated diseaseaging associated disordersaging associated mechanismaging mechanismaging pathwayaging populationaging related diseaseaging related disordersaging related mechanismaging related pathwaysaging resilienceallelic variantbiobankbiological mechanism of agebiological pathways of agebiorepositoryblood cell progenitorblood fractionationblood progenitorblood stem cellblood-forming stem cellbrain attackcardiovascular disordercentenarian human (100+)cerebral vascular accidentcerebrovascular accidentchromosomal defectchromosome defectclonal expansions in the bloodclonal hematopoiesisclones in hematopoietic cellscohortcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcytokinedecline in functiondecline in functional statusdefined contributiondetection limitdevelop therapydevelopmentaldisease associated with agingdisease of agingdisease riskdisorder of agingdisorder riskdisorders associated with agingdisorders related to agingdrug/agententire genomeepidemiologic investigationepidemiology studyfull genomefunctional declinefunctional status declinegenetic associationgenetic epidemiologic studygenetic epidemiologygenetic variantgenome mutationgenome scalegenome-widegenomewidegenomic datagenomic datasetgenomic effortgenomic strategygenomic variantgerm-line defectgermline varianthematopoietic cell cloneshematopoietic progenitorhematopoietic stem cell clonalityhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhepatic diseasehepatopathyhigh riskhuman genomicsimprovedin vivoin vivo Modelindividualized preventioninfection riskinsightintervention developmentintervention for preventionkidney disorderlife spanlife style interventionlifespanlifestyle interventionliver disorderlow-frequency mutationmalignancymechanism regulating agingmechanisms involved in agingmetabolism measurementmetabolomicsmetabonomicsmolecular modelingmortalitymosaicmosaic diseasesmosaic disordersmultidisciplinarymutantneoplasm/cancerneurological diseasenovelold ageontogenypathway involved in agingpersonalized preventionpoor health outcomepopulation agingprecision preventionprevention interventionpreventional intervention strategypreventive interventionprogramspromoterpromotorrare allelerare mutationrare variantreduced health outcomerenal disorderresilienceresilience during agingresilience in agingresilience in normal agingresilience to agingresilience with agingresilientresilient agingresilient to agingresistantrisk stratificationscientific accomplishmentsscientific advancessocial rolesomatic variantstratify riskstrokedstrokestargeted drug therapytargeted drug treatmentstargeted sequencingtargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmenttherapy developmenttreatment developmentwhole genomeworse health outcomeyoung adultyoung adult ageyoung adulthood
Description preview
Project Summary
With age, dividing cells acquire DNA mutations. A small number of these somatic mutations confer a selective
advantage leading to clonal outgrowth. In blood, this process is termed ‘clonal hematopoiesis’ (CH) which
includes both point mutations in cancer driver genes (eg. clonal hematopoiesis of indeterminate potential
‘CHIP’) and…
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