grant
Clonable Nanoparticles
Organization COLORADO STATE UNIVERSITYLocation FORT COLLINS, UNITED STATESPosted 1 Apr 2020Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AccelerationAddressAdoptedAmino Acid SequenceAmino AcidsBindingBinding ProteinsBiologic ModelsBiologicalBiological ModelsBiologyBismuthBody TissuesCaulobacterCell BodyCell ExtractsCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelChemicalsChimera ProteinChimeric ProteinsClosure by LigationCodonCodon NucleotidesCoenzyme IIColoring AgentsComplementComplement ProteinsComplexConsumptionContrast AgentContrast DrugsContrast MediaCryo-electron MicroscopyCryoelectron MicroscopyCustomCytochrome-B(5) ReductaseDNADarknessDataDehydrogenasesDeoxyribonucleic AcidDirected Molecular EvolutionDiseaseDisorderDrosophilaDrosophila genusDyesE coliE. coliElectron CryomicroscopyElectron MicroscopeElectron MicroscopyElectronsElementsEndowmentEngineeringEnzyme GeneEnzymesEscherichia coliEvaluationExposure toFilamentFixationFusion ProteinGenomicsGoalsGrantGreen Fluorescent ProteinsImageIn VitroIonsLabelLeannessLibrariesLigand BindingLigand Binding ProteinLigand Binding Protein GeneLigandsLigationMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMetalsMethodsMicroscopyModel SystemModelingModificationMolecularMolecular InteractionMorphologyNAD phosphateNAD(H) phosphateNADH phosphateNADH-Cytochrome B5 ReductaseNADPNADPHNegative Beta ParticleNegatronsNicotinamide-Adenine Dinucleotide PhosphateOrganismOxidoreductaseOxidoreductase GenePeptide LibraryPeptidesPhosphorousPhosphorusPolyphosphate kinasePolyphosphatesPrimary Protein StructureProceduresProductionPropertyProtein BindingProtein EngineeringProteinsProtomerRadiopaque MediaReducing AgentsReductantsReductasesRibosomal ProteinsRibosomesSe elementSeleniumShapesSolidSpecific qualifier valueSpecifiedSpectroscopySpectrum AnalysesSpectrum AnalysisStaining methodStainsStructureSubcellular ProcessSubstrate SpecificitySurfaceSystemTOMOThinnessTimeTissuesTomogramTriphosphopyridine Nucleotideaminoacidbiologicbound proteincell imagingcellular imagingcomplementationcryo-EMcryoEMcryogenic electron microscopycustomscytochrome b5 reductasedensitydesigndesigningdimerdirected evolutionenzyme substrateexperimentexperimental researchexperimental studyexperimentsfluorophorefruit flygenetic protein engineeringimaginginterestinternal controllight microscopyliving systemmicroscope imagingmicroscopic imagingmicroscopy imagingmodel organismmultiplexed imagingnanonano particlenano-sized particlenanoparticlenanosized particlenoveloptic imagingoptical imagingparticlepolyphosphate synthetaseprotein designprotein sequencereconstitutereconstitutionsample fixationscreeningscreeningssmall moleculetool
Description preview
PROJECT SUMMARY
The objective of this proposal is to address the contrast problem in cellular electron microscopy. The cloneable
fluorophore, Green Fluorescent Protein (GFP), and related fluorescent proteins complement small molecule
stains and dyes to essentially solve the contrast problem in optical imaging. For cellular electron microscopy,…
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