grant
Clinical utility of novel biomarkers for prediction of early pregnancy failure
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20261st trimesterAffectAreaBiologicalBiological MarkersBleedingBlood SerumCaringCause of DeathCessation of lifeCharacteristicsChronologic Fetal MaturityClinicalClinical ManagementClinical TrialsCognitive DiscriminationComplementComplement ProteinsConsumptionDataDeathDevelopment PlansDiagnosisDiagnosticDiagnostic FindingsDiscipline of obstetricsDiscriminationDiseaseDisorderEarly Placental PhaseEctopic PregnancyEthnic OriginEthnicityFallopian TubesFetal AgeFirst Pregnancy TrimesterFirst TrimesterFundingGestationGestational AgeGoalsGynecologicHealth Care TeamHemorrhageHigh Risk WomanHistoryHuman Chorionic GonadotropinIatrogenesisInterruptionLocationMachine LearningMammalian OviductsMedicalMedical Care TeamMethodologyMiscarriageModelingMorbidityNICHDNational Institute of Child Health and Human DevelopmentNational Institutes of HealthObstetricsPainPainfulPathway interactionsPatientsPerformancePhysiologyPopulationPredictive ValuePredictive Value of TestsPregnancyPregnancy OutcomeProceduresProcessProductivityProspective StudiesProspective cohortProteomicsRaceRacesRecording of previous eventsResearchResearch PriorityResearch ResourcesResourcesRiskRuptureSalpinxSamplingSerumSigns and SymptomsSpontaneous abortionStressSubgroupSymptomsSystemTestingTimeUncertaintyUnited States National Institutes of HealthUterine TubesUterusValidationWomanWomen's mortalityWorkat-risk femalesat-risk womenbio-markersbiologicbiologic markerbiomarkerbiomarker arraybiomarker developmentbiomarker panelbiomarker performancebiomarker utilityblood lossclassification algorithmclinical carecompanion diagnosticscomplementationdeath among femalesdeath among womendeath in femalesdeath in womendesigndesigningdiagnosis among femalesdiagnosis among womendiagnosis in femalesdiagnosis in womendiagnosis within femalesdiagnosis within womendiagnostic tooldoubtearly in pregnancyearly pregnanciesearly pregnancyearly pregnancy lossearly stage of pregnancyextrauterine pregnancyfailed pregnancyfeature selectionfemale deathfemale diagnosisfemale mortalityfemales at high riskhCGhealth and care deliveryhealth care deliveryhealth delivery systemshealth services deliveryhigh risk femaleshistoriesiatrogeniciatrogenicallyiatrogenicityimprovedinterestmachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmarker panelmodel buildingmortality among femalesmortality among womenmortality in femalesmortality in womennew markernovelnovel biomarkernovel markeroviductpain symptompainful symptompathwaypopulation basedpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpregnancy failureprospective research studyprospective surveyracialracial backgroundracial originrandom forestregression treesscreeningscreeningsultrasoundvalidationswombwomen at high riskwomen's deathwomen's diagnosis
Description preview
Abstract: The diagnosis and management for women who are at risk for ectopic pregnancy (EP) and
spontaneous abortion (SAB), has not changed substantially in decades. While ultrasound can diagnose a
significant portion of women at presentation, because of its limited accuracy in abnormal and early gestation, a
large number of women need serial…
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