grant
Clinical utility of leptin therapy in syndromic forms of insulin resistance.
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AdipocytesAdipose CellAdipose tissueAgonistAmino AcidsAnimal ModelAnimal Models and Related StudiesAntibodiesBerardinelli syndromeBerardinelli-Seip Congenital LipodystrophyBerardinelli-Seip-Lawrence syndromeBiologyBlood GlucoseBlood SugarBody TissuesBody Weight decreasedClinicalClinical TrialsDNA mutationDiseaseDisorderEatingEndocrineEndocrine Gland SecretionEndocrine GlandsEndocrine OrgansExcretory functionFDA approvedFamilial generalized lipodystrophyFastingFat CellsFatsFatty TissueFatty acid glycerol estersFood IntakeGene AlterationGene MutationGeneralized Lipoatrophic Diabetes MellitusGenesGenetic ChangeGenetic defectGenetic mutationGlycohemoglobin AGlycosylated hemoglobin AGoalsHb A1Hb A1a+bHb A1cHbA1HbA1cHeart HypertrophyHemoglobin A(1)HormonesHuB219HumanHumulin RInsulinInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin ResistanceInsulin-Dependent Tyrosine Protein KinaseInterventionLEP-RLEPR ProteinLawrence syndromeLeptinLeptin deficiencyLeptin resistanceLipocytesLipodystrophyLiverLiver Function TestsMature LipocyteMature fat cellMeasuresMetabolicMiceMice MammalsMiescher syndrome 2Modern ManMorbid ObesityMurineMusMutationNASHNovolin ROB ReceptorOB-ROb Gene ProductOb ProteinObese Gene ProductObese MiceObese ProteinObesityOxidative StressPatientsProteinsQOLQuality of lifeRegular InsulinReplacement TherapyRodentRodentiaRodents MammalsSafetySeip syndromeSevere obesitySeveritiesSteatohepatitisTherapeutic HormoneTissuesTriacylglycerolTriglyceridesUrineWeightWeight LossWeight ReductionWorkadipocytokinesadipogenesisadipokinesadiposeadiposityaminoacidbody weight losscardiac hypertrophyclinical efficacycongenital lipoatrophic diabetescongenital lipodystrophycorpulenceexcretionextreme obesityfastedfastsgene defectgeneralized lipodystrophygenome mutationhemoglobin A1chepatic body systemhepatic organ systemimprovedinsulin resistantinsulin toleranceleptin receptorleptin-binding proteinlipid biosynthesislipodystrophy-acromegaloid gigantism syndromelipogenesismodel of animalmutant allelenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-alcohol induced steatohepatitisnon-alcoholic steato-hepatitisnon-alcoholic steatohepatitisnonalcoholic steato-hepatitisnonalcoholic steatohepatitisnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyob/ob mousepolypeptidereproductive functionweightswhite adipose tissuewt-lossyellow adipose tissue
Description preview
Leptin was discovered when the gene mutation in the ob/ob mouse, an animal model of obesity, was identified. Leptin is a polypeptide of 167 amino acids that is encoded by the obese (ob) gene. Ob/ob mice make a defective leptin product and are extremely obese and hyperphagic. Since leptin administration causes a dramatic reduction in weight and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click