grant
Clinical Translation of a Urine-Based Biomarker for the Detection of Residual Disease in Radical Cystectomy Candidates
Organization RESEARCH INST OF FOX CHASE CAN CTRLocation PHILADELPHIA, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AbscissionAccreditationActive Follow-upAddressAdjuvant ChemotherapyAdjuvant Drug TherapyAgingAlgorithmic AnalysesAlgorithmic AnalysisAlgorithmsAnalyses of AlgorithmsAnalysis of AlgorithmsAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsArchivesAutomationBiological MarkersBiopsyBladderBladder CancerBladder Urinary SystemBladder removalCDDPCLIA accreditedCLIA approvedCLIA certifiedCLIA compliantCLIA licensedCancer PatientCancer cell lineCancerousCancersCell Communication and SignalingCell SignalingCharacteristicsCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClinicalClinical ProtocolsClinical TrialsClinical assessmentsCopy Number PolymorphismCysplatynaCystectomyCystoscopyCytologyDNADNA AlterationDNA SequenceDNA Sequence AlterationDNA copy numberDNA mutationData AnalysesData AnalysisDecision MakingDeoxyribonucleic AcidDetectable Residual DiseaseDetectionDevelopmentDichlorodiammineplatinumDiseaseDisorderExcisionExtirpationFinancial costFox Chase Cancer CenterFundingFutureGene variantGenetic AlterationGenetic ChangeGenetic MaterialsGenetic defectGenetic mutationGoalsGuidelinesImageIn complete remissionInduction TherapyIntra-Observer VariabilityIntra-Observer VariationIntracellular Communication and SignalingIntraobserver VariabilityIntraobserver VariationsJudgmentLaboratoriesLibrariesLife StyleLifestyleMalignant Bladder NeoplasmMalignant NeoplasmsMalignant TumorMalignant Tumor of the BladderMalignant neoplasm of urinary bladderManualsMapsMeasuresMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMinimal Residual DiseaseMonitorMorbidityMuscleMuscle TissueMutationNEOADJNGS MethodNGS systemNatureNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentNeoplasm MetastasisNucleotidesOncologistOperative ProceduresOperative Surgical ProceduresOutcomePathologicPatientsPerformancePerioperativePeyrone's ChloridePeyrone's SaltPhasePhysiciansPlatinum DiamminodichloridePositionPositioning AttributePreoperative CarePreparationProcessProspective StudiesRadical CystectomyRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorRemovalResearchResearch SpecimenResidualResidual NeoplasmResidual TumorsResidual stateRetrospective StudiesRiskRunningSafetySamplingSecondary NeoplasmSecondary TumorSequence AlterationSignal TransductionSignal Transduction SystemsSignalingSpecificitySpecimenStructureSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalTestingTimeTranslationsTumor TissueUrinary Bladder CancerUrinary Bladder Malignant TumorUrinary DiversionUrineUrostomyValidationVariantVariationaccreditedactive followupallelic variantanalysis pipelinebio-markersbiologic markerbiological signal transductionbiomarkerbladder surgerycancer metastasischemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapychemotherapycis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumclinical practiceclinical translationclinically translatableco-morbidco-morbiditycomorbiditycomplete responsecopy number variantcopy number variationdata interpretationdetection limitdevelopmentalexperiencefollow upfollow-upfollowed upfollowupgenetic profilinggenetic variantgenome mutationgenomic alterationgenomic variantimagingimprovedindelinduction therapiesinsertion/deletioninsertion/deletion mutationinterestinternal controlintravesicalmalignancymolecular diagnosticsmonetary costmortalitymuscle invasive bladder cancermuscularneoplasm recurrenceneoplasm/cancernext gen sequencingnext generation sequencingnextgen sequencingperformance testspreparationspreservationprimary outcomeprognostic assaysprognostic testprospectiveprospective research studyprospective surveyradio-chemo-therapyradio-chemotherapyradiochemotherapyresectionresidual diseaseretrospective research studyretrospective surveystandard of caresurgerysurvival outcometime usetissue biomarkerstooltranslationtumortumor cell metastasisurinaryurinary bladderurologicurologicalvalidations
Description preview
PROJECT SUMMARY/ABSTRACT
Radical cystectomy, which is used to treat some patients with localized bladder cancer, is associated with
significant lifestyle changes due to the requirement of urinary diversion through a urostomy, significant financial
costs, and significant risk for perioperative surgical morbidity and mortality. Because of negative…
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