grant

Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)

Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 30 Sept 2014Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AccelerationAddressAdvocacyAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAmyotrophic lateral sclerosis and frontotemporal degenerationAmyotrophic lateral sclerosis and frontotemporal dementiaArticulationBiologicalBiological MarkersBiologyBiotechBiotechnologyC9ORF72CausalityClinicalClinical InvestigatorClinical ResearchClinical StudyClinical TrialsCollaborationsCommunitiesComplexDataData CollectionDedicationsDegenerative Neurologic DisordersDevelopment PlansDevelopment and ResearchDiagnosisDiagnosticDiseaseDisease ProgressionDisorderElectronic Health RecordEnsureEtiologyEvaluationFTD/ALSFTLD/ALSFosteringFoundationsFrontotemporal Lobar Degeneration/Amyotrophic lateral sclerosisFundingFutureGehrig's DiseaseGeneticGenomicsGenotypeGoalsHMSN Type VHereditary Motor-Sensory Neuropathy with Pyramidal SignsHereditary Spastic ParaplegiaHeritabilityHeterogeneityInfrastructureInvestigatorsLateral SclerosisLinguisticLinguisticsLou Gehrig DiseaseMotorMotor CellMotor NeuronsMuscle DiseaseMuscle DisordersMuscular DiseasesMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyNational Institutes of HealthNatural HistoryNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsOrphan DiseasePatient Outcomes AssessmentsPatient ParticipationPatient Participation RatesPatient Reported MeasuresPatient Reported OutcomesPatientsPhasePhenotypePhysiciansPilot ProjectsPlayPrecision therapeuticsPredispositionPrimary Lateral SclerosisProgressive Muscular AtrophyProgressive Myelopathic Muscular AtrophyProteomicsR & DR&DRare DiseasesRare DisorderRegistriesResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskSaint JudeSaint Jude Children's Cancer CenterSaint Jude Children's Research HospitalSamplingScienceScientistSeriesSpastic Paraplegia-Hypertrophic Motor-Sensory NeuropathySt. JudeSt. Jude Children's Cancer CenterSt. Jude Children's Research HospitalSt. Jude Children's Research Hospital Comprehensive Cancer CenterSt.Jude Children's Cancer CenterSt.Jude Children's Research HospitalSt.Jude Children's Research Hospital Comprehensive Cancer CenterSurrogate MarkersSusceptibilitySymptomsSystemTechnologyTrainingType V Hereditary Motor and Sensory NeuropathyUnited States National Institutes of HealthVisualizationamyotrophic lateral sclerosis with frontotemporal dementiaamyotrophic lateral sclerosis/FTLDamyotrophic lateral sclerosis/frontotemporal dementiaamyotrophic lateral sclerosis/ftdbio-markersbiobankbiologicbiologic markerbiological heterogeneitybiomarkerbiomarker validationbiorepositorycareercareer developmentcausationchromosome 9 open reading frame 72clinical outcome assessmentclinical outcome measuresclinical translationclinical trial readinessclinically translatabledata portaldata sharing portaldata toolsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelop therapydisease causationdisease heterogeneitydrug developmenteffective therapyeffective treatmentelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordentire genomefrontotemporal dementia-amyotrophic lateral sclerosisfrontotemporal lobar dementia amyotrophic lateral sclerosisfull genomegenetic architecturegenomic datagenomic datasetinterdisciplinary approachintervention developmentlong read seqlong-read sequencinglong-read transcript sequencingmarker validationmotoneuronmulti-modal datamulti-modal datasetsmultidisciplinarymultidisciplinary approachmultimodal datamultimodal datasetsmultisystem proteinopathymuscular disorderneurodegenerative illnessneuronalnew markernovelnovel biomarkernovel markerorphan disorderoutreachpatient advocacy grouppatient populationpilot studyprecision therapiesprecision treatmentprognosticprogramsprogressive spinal muscular atrophyresearch and developmentresearch studyresponsesurrogate bio-markerssurrogate biomarkerstherapeutic agent developmenttherapeutic developmenttherapy developmenttooltranslational investigatortranslational researchertranslational scientisttreatment developmentwhole genome
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PROJECT SUMMARY (Overall)
The Clinical Research in ALS and related disorders for Therapy Development (CReATe) Consortium is a Rare

Diseases Clinical Research Consortium (RDCRC) that forms part of the National Institutes of Health Rare

Diseases Clinical Research Network (RDCRN). CReATe comprises a multi-disciplinary group of clinicians,

scientists,…

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Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) — UNIVERSITY OF MIAMI SCHOOL OF MEDI | Dev Procure