grant
Clinical Implementation of Blood Pressure Polygenic Risk Score: A Randomized Clinical Trial
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20252-arm study21+ years oldASCVDActive Follow-upAdherenceAdultAdult HumanAgeAmbulatory Blood Pressure MonitoringAnti-Hypertensive AgentsAnti-Hypertensive DrugsAnti-HypertensivesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAttitudeBP controlBP managementBehavioralBeliefBlood GlucoseBlood PressureBlood SugarBody CompositionCLIA accreditedCLIA approvedCLIA certifiedCLIA compliantCLIA licensedCardiometabolic DiseaseCardiometabolic DisorderCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCaringChlorphthalidoloneChlorthalidoneClinicClinicalCounselingDEXADXADataDevelopmentDiastolic PressureDiastolic blood pressureDietDisclosureDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryEducationEducational MaterialsEducational aspectsEnrollmentEnvironmental FactorEnvironmental Risk FactorEquilibriumEventExerciseFaceFamilyFatsFatty acid glycerol estersFemaleFutureGene variantGeneticGenetic CounselingGenetic DiversityGenetic RiskGenetic VariationGenomicsGenotypeGlycohemoglobin AGlycosylated hemoglobin AGoalsHb A1Hb A1a+bHb A1cHbA1HbA1cHealthHealth PrioritiesHealth behaviorHealth behavior changeHealthy EatingHeart VascularHemoglobin A(1)HeritabilityHourHypertensionHypotensive AgentHypotensive DrugsIndividualInformation DisclosureIntentionInterventionInvestigatorsKnowledgeLeannessLifeLipidsMarsMeasuresMediatingMediationModelingNHANESNational Health and Nutrition Examination SurveyNegotiatingNegotiationOutcomeOutcome StudyOxodolineParticipantPatient Self-ReportPatientsPersonsPhthalamudinePhysical activityPlanet MarsPopulationPredicting RiskPredispositionPremature MortalityPreventative interventionPreventionQuestionnairesRandomizedRandomized Controlled Clinical TrialsRandomized, Controlled TrialsResearch PersonnelResearchersRiskRisk FactorsRoleScanningSecondary toSelf-ReportShapesSmokingSmoking StatusSocial ObligationsSpecific qualifier valueSpecifiedSusceptibilityThinnessTimeUS Department of AgricultureUSDAUnhealthy DietUnited StatesUnited States Department of AgricultureVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderVisitWorkactigraphactigraphyactive followupadult youthadulthoodagedagesallelic variantanti-hypertensionarmatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebalancebalance functionbehavior adherencebehavior changebehavior outcomebehavioral adherencebehavioral outcomeblood pressure controlblood pressure elevationblood pressure managementburden of diseaseburden of illnesscardiometaboliccardiometabolismcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular healthcardiovascular riskcardiovascular risk factorcareercirculatory systemclinical careclinical implementationclinical relevanceclinically relevantcohortcompliance behaviordetermine efficacydevelopmentaldietsdisease burdendrug adherencedrug complianceearly onsetefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelevated blood pressureenrollenvironmental riskevaluate efficacyexamine efficacyexperiencefacesfacialfollow upfollow-upfollowed upfollowupforecasting riskgenetic consultationgenetic variantgenome scalegenome-widegenomewidegenomic varianthealth beliefhealth goalshealth related behaviorhealth related quality of lifehealth-related beliefhealthy lifestylehemoglobin A1chigh blood pressurehyperpiesiahyperpiesishypertension controlhypertension managementhypertensivehypertensive diseasehypertensive disorderimprovedincrease in blood pressureincreased blood pressureindexingintervention for preventionlack of physical activitymedication adherencemedication compliancemid lifemid-lifemiddle agemiddle agedmidlifeparticipant enrollmentpatient enrollmentphysical inactivitypolygenetic risk scorespolygenic risk scorepoor dietpredict responsivenesspredict riskpredict riskspredicted riskpredicted riskspredicting responsepredicting riskspredictive riskpredicts riskprevention interventionpreventional intervention strategypreventive interventionprimary outcomerandomisationrandomizationrandomized control clinical trialrandomized control trialrandomized, clinical trialsrandomly assignedrisk predictionrisk predictionsroutine caresecondary outcomesexsleep amountsleep durationsleep episodesleep intervalsleep lengthsleep periodsleep quantitysleep timesocial roletime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtraittwo-arm studyyoung adultyoung adult ageyoung adulthoodyounger age♀
Description preview
Elevated blood pressure (BP) is the single greatest modifiable contributor to premature mortality globally. The development of hypertension (HTN) and associated adverse cardiovascular (CV) events is contributed by an interplay of genetic and environmental factors. We constructed a genome-wide systolic BP (SBP) polygenic risk score (PRS),…
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