grant
Clinical Impact of the Cefazolin Inoculum Effect
Organization METHODIST HOSPITAL RESEARCH INSTITUTELocation HOUSTON, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years oldAddressAdverse reactionsAffectAntibiotic AgentsAntibiotic DrugsAntibioticsAttentionAustraliaBacteremiaBiologicalBlood CirculationBloodstreamBone InfectionCanadaCefazolinCephalosporinsChildChild YouthChildren (0-21)ChileClinicalClinical DataClinical MicrobiologyColombiaDataDetectionDrugsEarly DiagnosisEffectivenessEnrollmentFailureFloxacillinFlucloxacillinFluorochloroxacillinG24 proteinGenerationsGenomicsGenus staphylococcusGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGoalsHepatotoxic effectHepatotoxicityInfectionInterstitial NephritisIsraelLaboratoriesLatin AmericaLifeLiver ToxicityMRSAMSSAMediatorMedicationMethicillin Resistant S. AureusMethodist ChurchMethodistsMinimum Inhibitory Concentration measurementMinimum Inhibitory ConcentrationsMiscellaneous AntibioticNafcilNafcillinNallpenNaphthamidopenicillinNatureNeutropeniaNew ZealandOsteomyelitisOutcomeOxacillinOxazocillinePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPenicillinsPerformancePharmaceutical PreparationsPhenotypePrevalenceProductionPublishingRandomizedReactionRestRetrospective StudiesRiskRisk FactorsS aureusS. aureusS. aureus infectionSafetySample SizeSensitivity and SpecificitySingaporeSpecific qualifier valueSpecifiedStaph aureusStaph aureus infectionStaphylococcusStaphylococcus aureusStaphylococcus aureus infectionTest ResultTestingTherapeuticToxic effect on liver cellsUnited KingdomUnited Statesarmassess effectivenessbacteraemiabacterial bloodstream infectionbacterial infection in the bloodstreambeta lactam antibioticbeta lactam hydrolasebeta-Lactamasebeta-Lactamhydrolasebeta-Lactamsbiologicblood infectionbloodstream infectionclinical relevanceclinically relevantcostdetermine effectivenessdiagnostic tooldrug/agentearly detectioneffectiveness assessmenteffectiveness evaluationenrollevaluate effectivenessexamine effectivenessgeographic sitehepatic toxicityhepatoxicityhigh riskhuman pathogeninfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinfection in the bloodinfection of the bloodinsightkidsmethicillin resistance Staphylococcus aureusmethicillin resistant Staphylococcus aureusmethicillin resistant strains of Staphylococcus aureusmethicillin sensitive S . aureusmethicillin sensitive Staphylococcus aureusmethicillin susceptible Staphylococcus aureusmethicillin-susceptible S. aureusminimal inhibitory concentrationmortalitynew diagnosticsnext generation diagnosticsnitrocefinnovelnovel diagnosticsopen labelopen label studyparticipant enrollmentpathogenpatient enrollmentpatient oriented outcomesprimary outcomepublic health relevancerandomisationrandomizationrandomly assignedrapid assayrapid detectionrapid testrapid testsrecruitsecondary outcomesuccesstherapy optimizationtreatment optimizationyoungsterβ lactam antibioticβ-Lactamaseβ-Lactams
Description preview
ABSTRACT
Staphylococcus aureus is a major human pathogen responsible for a wide range of life-threatening infections.
Many of these infections are caused by methicillin-susceptible S. aureus (MSSA). MSSA represent a major
burden among S. aureus infections and are important contributors to mortality. For decades, the first line of
therapy for…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click