grant
Clinical Core
Organization NORTHERN CALIFORNIA INSTITUTE/RES/EDULocation SAN FRANCISCO, UNITED STATESPosted 30 Sept 2004Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AD dementiaAPOE e4APOE-ε4APOEε4AccelerationActive Follow-upAdoptedAfrican AmericanAfro AmericanAfroamericanAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease therapeuticAlzheimer's therapeuticAlzheimers DementiaAmentiaAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAssayAutopsyAβBioassayBiological AssayBiological MarkersBlackBlack raceBlood PlasmaClinicClinicalClinical DataClinical ManagementClinical TrialsClinical Trials DesignClinical assessmentsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsCollectionContracting OpportunitiesContractsDataData CollectionDementiaDiseaseDisorderDisturbance in cognitionDrugsEnrollmentFinancial ManagementFreezingFutureGenetic MarkersGroups at riskImageImpaired cognitionIndividualInternetInvestigationLatineLatinxLongitudinal StudiesMT-bound tauMaintenanceMeasuresMedicationMissionMonitorNerve DegenerationNeurobiologyNeuron DegenerationOccupational activity of managing financesOn-Line SystemsOnline SystemsPETPET ScanPET imagingPETSCANPETTParticipantPathologyPeople at riskPersonsPersons at riskPharmaceutical PreparationsPhlebotomyPlasmaPlasma SerumPopulationPopulation GroupPopulations at RiskPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredictive ValuePrimary Senile Degenerative DementiaProceduresProcessQuality ControlRad.-PETResearch InstituteReticuloendothelial System, Serum, PlasmaRiskSiteTauopathiesTherapeutic ResearchTherapeutic TrialsUnderrepresented GroupsUnderrepresented PopulationsVenous blood samplingWWWa beta peptideabetaactive followupamyloid betaamyloid-b proteinapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4behavior measurementbehavioral measurebehavioral measurementbeta amyloid fibrilbio-markersbiologic markerbiomarkerclinical centercognitive assessmentcognitive dysfunctioncognitive losscognitive performancecognitive testingcohortcommunity researchcomputerizeddata managementdesigndesigningdrug developmentdrug/agentenrollfollow upfollow-upfollowed upfollowupfunctional outcomesgene biomarkergene expression biomarkergene markergene signature biomarkergenetic analysisgenetic biomarkerhigh riskimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerlong-term studylongitudinal data setlongitudinal datasetlongitudinal outcome studieslow SESlow socio-economic positionlow socio-economic statuslow socioeconomic positionlow socioeconomic statusmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentnecropsyneural degenerationneural imagingneuro-imagingneurobiologicalneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologic tauneuropathological taunovelonline computeroperationoperationsoutreachp-taup-τparticipant retentionphospho-tauphospho-τphosphorylated taupolygenetic risk scorespolygenic risk scorepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of taupostmortemposttranslational modification of taupreservationprimary degenerative dementiarecruitremote assessmentremote evaluationsenile dementia of the Alzheimer typesocial culturesocio-culturalsocioculturalsoluble amyloid precursor proteintautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytooltrial designunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplewebweb basedworld wide webτ Proteinsτ phosphorylation
Description preview
Clinical Core: Summary/Abstract
The Clinical Core serves two primary functions for the ADNI project: day-to-day coordination of all clinical
activities at the ADNI sites, and oversight of the scientific clinical aims. Project management, regulatory
oversight, site management and monitoring, clinical data collection and management and site…
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