grant
Clinical Core - Core 1 - Brewington
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Aug 2018Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20250-11 years oldAddressAgingBasic ResearchBasic ScienceBiologic ModelsBiologicalBiological MarkersBiological ModelsBiologyBiometricsBiometryBiostatisticsBlood SerumBody TissuesBowel CancerBowel ObstructionBronchoalveolar Lavage FluidBronchoscopyCF patientsCF related diabetesCFTRCFTR ProteinCaliforniaCaringCell BodyCellsCenter Core GrantsChildChild YouthChildren (0-21)Children's HospitalChloride ChannelsChloride Ion ChannelsClinicalClinical ResearchClinical StudyClinical TrialsCollaborationsColon and Rectal SurgeryColorectal SurgeryCommunitiesComplementComplement ProteinsConsultationsCoupledCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDNA mutationData AnalysesData AnalysisDeath RateDefectDelta F508 mutationDiseaseDisorderEnrollmentEnsureEvaluationF508 deletionF508 mutationF508-delF508delFundingGastroenterologyGene variantGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationHealthHepatic DisorderHumanIRBIRBsImageIndividualInfantInfrastructureInstitutionInstitutional Review BoardsInternationalIntestinal CancerIntestinal ObstructionInvestigator-Initiated ResearchInvestigatorsLab FindingsLaboratory FindingLinkLiquid substanceLiver diseasesLungLung Respiratory SystemMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant Intestinal NeoplasmMalignant Intestinal TumorMalnutritionMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedical centerModel SystemModern ManMonitorMucoviscidosisMutationNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingNutritional DeficiencyOnset of illnessOperative ProceduresOperative Surgical ProceduresOutcomeOutcome MeasureP30 AwardP30 GrantP30 MechanismP30 ProgramPathologyPatient CarePatient Care DeliveryPatientsPediatric HospitalsPersonsPhysiologicPhysiologicalPneumologyPneumonologyPopulationPrecision carePredispositionProcessProductivityPulmonary MedicinePulmonary imagingPulmonologyR-Series Research ProjectsR01 MechanismR01 ProgramRegulator GenesResearchResearch GrantsResearch InfrastructureResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearch SupportResearchersResourcesSafetySamplingSerumSightSiteSourceSpirometrySputumStandardizationSubgroupSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTissuesTrainingTranscriptional Regulatory ElementsTranslational ResearchTranslational ScienceTranslationsUndernutritionUnited StatesUniversitiesVisionZeugmatographyallelic variantbio-markersbiologicbiologic markerbiomarkercare for patientscare of patientscaring for patientsclinical efficacyclinical investigationcohortcolon and rectum surgerycomplementationconsultationcystic fibrosis patientscystic fibrosis related diabetescystic fibrosis transmembrane regulatordata interpretationdatabase of Genotypes and PhenotypesdbGaPdesigndesigningdietary deficiencydisease modeldisease onsetdisorder modeldisorder onsetearly onsetempowermentenrollfluidgastrointestinalgenetic trans acting elementgenetic variantgenome mutationgenomic varianthepatic diseasehepatopathyimagingimprovedindexingindividual patientindividualized careindividualized patient careindividuals with CFindividuals with cystic fibrosisintervention designintestine cancerintestine obstructionkidsliquidliver disorderlow-frequency mutationlung imaginglung scanningmalignant intestine neoplasmmalignant intestine tumormalnourishedmeasurable outcomemortality ratemortality rationovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderoutcome measurementpatient centeredpatient orientedpatient populationpatients with CFpatients with cystic fibrosispersonalized carepersonalized patient careprogramsrare allelerare mutationrare variantregulatory generesponsesuccesssurgerytherapy designtrans acting elementtranslationtranslation researchtranslational investigationtranslational investigatortranslational researchertranslational scientisttranslational studytreatment designventilationvisual functionyoungsterΔF508
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PROJECT SUMMARY / ABSTRACT
A foundational component of this P30 application is the Personalized Clinical Core, which spans Cincinnati Children's Hospital Medical Center (CCHMC), University of Cincinnati (UC), and Cedars Sinai Medical Center (CSMC). With the primary site at CCHMC, this core leverages strengths in CFTR biology, clinical trials, and…
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