grant
Clinical Core
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 15 May 2020Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025AD dementiaAD preventionActive Follow-upAddressAdoptionAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAmyloidAmyloid SubstanceAreaAutopsyBackBehavioralBiologicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesBrainBrain Nervous SystemBrain imagingCare GiversCaregiversClassificationClinicalClinical DataClinical EvaluationClinical ServicesClinical TestingClinical TrialsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsCommunitiesConsensusConsentDNADataData BasesData CollectionDatabasesDementiaDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDiagnosticDisadvantagedDiseaseDisorderDisturbance in cognitionDiverse WorkforceDorsumEconomically DeprivedEducationEducational aspectsEncephalonEnrollmentEnsureEquityEthnic OriginEthnicityEvaluationFundingFutureGeneticGenetic MarkersGoalsGrantHistoryImageImpaired cognitionImpairmentIndividualInternationalInterventionInvestigationInvestigatorsKnowledgeLeadershipLife CycleLife Cycle StagesMT-bound tauMeasuresMonitorNatural HistoryNeighborhoodsNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronal InjuryNeuronsParticipantPathogenicityPathologyPhenotypePilot ProjectsPlasmaPlasma SerumPopulationPrevention trialPrimary Senile Degenerative DementiaProcessR-Series Research ProjectsR01 MechanismR01 ProgramRaceRacesRecording of previous eventsResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearch SupportResearchersResourcesReticuloendothelial System, Serum, PlasmaRiskSamplingStagingSystematicsTimeTissuesTrainingUniversitiesVisitWorkWorkplace Diversityactive followupbio-markersbiologicbiologic markerbiomarkerbrain visualizationclinical diagnosisclinical diagnosticsclinical testcognitive assessmentcognitive dysfunctioncognitive losscognitive testingcohortdashboarddata basedata managementdementia burdendeprivationdevelopmentaldigital cognitive assessmentdigital cognitive testeconomic disparityeconomically disadvantagedenrollexposomeflexibilityflexiblefollow upfollow-upfollowed upfollowupgene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkerhistoriesimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerindexinglife coursemedical diagnosticmeetingmeetingsmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentnecropsyneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurogeneticsneuroimagingneuroimaging biomarkerneuroimaging markerneurological degenerationneurological imagingneuron injuryneuronalneuronal degenerationneuropathologicneuropathologicalneuropathologynext generationnovelonline screeningoutreachparticipant enrollmentpatient enrollmentpilot studypostmortemprimary degenerative dementiaprogramspsychiatric co-morbiditypsychiatric comorbidityracialracial backgroundracial diversityracial originracially diverserecruitreferral servicesresearch clinical testingresearch studyresilienceresilientsenile dementia of the Alzheimer typesocial health determinantssocio-economicsocio-economicallysocioeconomicallysocioeconomicsstatistical analysis corestatistical corestatistics corestatistics research corestructural determinantsstructural factorssuccesstautau Proteinstau factortrial readinessτ Proteins
Description preview
Clinical Core Abstract
Disease (AD) depends
: Progress in early risk detection, diagnosis, treatment, and prevention of Alzheimer’s
critically on the availability of large “trial-ready” cohorts of participants spanning a
spectrum from cognitively unimpaired to MCI-risk stages including subjective cognitive decline, mild cognitive
impairment (MCI),…
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