grant
Clinical Core
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 15 May 2020Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026AD and related dementiaAD biological markerAD biomarkerAD dementiaAD pathologyAD preventionAD related biomarkerAD related dementiaAD riskAD risk factorADRDActive Follow-upAddressAdoptionAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related biomarkerAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's pathologyAlzheimer's related biomarkerAlzheimers DementiaAlzheimer’s biological markerAmentiaAmyloidAmyloid SubstanceAreaAutopsyBackBehavioralBiologicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesBrainBrain Nervous SystemBrain imagingCare GiversCaregiversClassificationClinicalClinical DataClinical EvaluationClinical ServicesClinical TestingClinical TrialsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsCommunitiesConsensusConsentDNADataData BasesData CollectionDatabasesDementiaDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDiagnosticDisturbance in cognitionDorsumEducationEducational aspectsEncephalonEnrollmentEnsureEvaluationFundingFutureGeneticGenetic MarkersGoalsGrantHistoryImageImpaired cognitionImpairmentIndividualInternationalInterventionInvestigationInvestigatorsKnowledgeLeadershipLife CycleLife Cycle StagesMT-bound tauMeasuresMonitorNatural HistoryNeighborhoodsNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronal InjuryNeuronsParticipantPathogenicityPathologyPhenotypePilot ProjectsPlasmaPlasma SerumPopulationPrevention trialPrimary Senile Degenerative DementiaProcessR-Series Research ProjectsR01 MechanismR01 ProgramRecording of previous eventsResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearch SupportResearchersResourcesReticuloendothelial System, Serum, PlasmaRiskSamplingStagingSystematicsTimeTissuesTrainingUniversitiesVisitWorkactive followupalzheimer riskbio-markersbiologicbiologic markerbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseasebrain visualizationclinical diagnosisclinical diagnosticsclinical testcognitive assessmentcognitive dysfunctioncognitive losscognitive testingcohortdashboarddata basedata managementdementia burdendeprivationdevelopmentaldigital cognitive assessmentdigital cognitive testenrollexposomeflexibilityflexiblefollow upfollow-upfollowed upfollowupgene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkerhigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhistoriesimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedindexinglife coursemedical diagnosticmeetingmeetingsmicrotubule bound taumicrotubule-bound taumild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentnecropsyneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurogeneticsneuroimagingneuroimaging biomarkerneuroimaging markerneurological degenerationneurological imagingneuron injuryneuronalneuronal degenerationneuropathologicneuropathologicalneuropathologynext generationnovelonline screeningoutreachparticipant enrollmentparticipant retentionpatient enrollmentpilot studypostmortemprimary degenerative dementiaprogramspsychiatric co-morbiditypsychiatric comorbidityrecruitreferral servicesresearch clinical testingresearch studyresilienceresilientrisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'ssenile dementia of the Alzheimer typestatistical analysis corestatistical corestatistics corestatistics research coresuccesstautau Proteinstau factortrial readinessτ Proteins
Description preview
Clinical Core REVISED Abstract:
Progress in early risk detection, diagnosis, treatment, and prevention of Alzheimer’s Disease (AD) depends critically on the availability of large “trial-ready” cohorts of participants spanning a spectrum from cognitively unimpaired to MCI-risk stages including subjective cognitive decline, mild cognitive…
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