grant
Clinical and functional assessment of glaucoma-associated mitochondrial gene variants to facilitate precision eye care
Organization MASSACHUSETTS EYE AND EAR INFIRMARYLocation BOSTON, UNITED STATESPosted 1 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20253-Pyridinecarboxamide3-Pyridinecarboxylic AcidActive OxygenAffectAgeAntioxidantsAutoregulationAxonBioinformaticsBlindnessBlood VesselsBone-Derived Transforming Growth FactorCaringCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell ProtectionCell SignalingCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessClinicClinicalClinical DataClinical ResearchClinical StudyCodeCoding SystemCoenzyme IICommunitiesConsumptionCytoprotectionDataData BasesData ScienceDatabasesDevelopmentDevelopment PlansDevicesDiagnosisDiseaseDisorderDysfunctionECMEarEnvironmentEnvironmental FactorEnvironmental Risk FactorEnvironmental ToxinExerciseExtracellular MatrixEyeEyeballFellowshipFollow-Up StudiesFollowup StudiesFoundationsFunctional disorderFundingFutureGWA studyGWASGene CombinationsGene variantGenesGeneticGenetic RiskGenetic studyGlaucomaGlutathioneGoalsH2O2Health Care ProfessionalHealth ProfessionalHomeostasisHumanHydrogen PeroxideHydroperoxideImageImpairmentIn VitroIndividualInjuryIntakeIntracellular Communication and SignalingIntraocular PressureInvestigatorsLife StyleLifestyleMeasuresMembrane PotentialsMentorsMentorshipMeta-AnalysisMethodologyMilk Growth FactorMitochondriaModelingModern ManMolecularMonitorMorphologyNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNational Institutes of HealthNiacinNiacinamideNicotinamideNicotinamide-Adenine Dinucleotide PhosphateNicotinamidumNicotinic AcidsNicotinic acid amideNicotylamideNurses' Health StudyOcular TensionOptic DiskOptic Nerve HeadOptic PapillaOxidation-ReductionOxygen RadicalsPOAGPathogenesisPathogenicityPathway interactionsPatient RecruitmentsPatientsPatternPellagra-Preventing FactorPeripheralPersonalized medical approachPhysiologic Intraocular PressurePhysiological HomeostasisPhysiopathologyPlatelet Transforming Growth FactorPopulationPrecision Medicine InitiativePredispositionPrevalencePreventionPrimary Open Angle GlaucomaPro-OxidantsProductionReactive Oxygen SpeciesRedoxResearchResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesResting PotentialsRetinaRetinal Ganglion CellsRiskRisk FactorsRisk-associated variantRoleScientistSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSmokingStudy TypeSubcellular ProcessSuperoxide AnionSuperoxide RadicalSuperoxidesSusceptibilityTGF BTGF-betaTGF-βTGFbetaTGFβTestingToxic Environmental AgentsToxic Environmental SubstancesTrabecular MeshworkTrabecular meshwork structureTraining ProgramsTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslatingTransmembrane PotentialsTriphosphopyridine NucleotideTrxR2 enzymeUnited States National Institutes of HealthVariantVariationVisual FieldsVitamin B 3Vitamin B3Vitamin PPWorkagesallelic variantaqueousarchetypal analysisbiobankbiological signal transductionbiorepositorycareercareer developmentclinical careclinical phenotypecommon treatmentcytoprotectivedata basedesigndesigningdevelopmentaldisease diagnosisdisease severitydisease subgroupsdisease subtypedisorder subtypeenvironmental riskenvironmental toxicantex vivo perfusioneye fieldgamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycinegene functiongene locusgenetic locusgenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusgenomic variantglaucomatoushigh intra-ocular pressurehigh intraocular pressurehuman progenitor cell derivedhuman stem cell-derivedimagingimprovedindividualized approachinjuriesintra-ocular pressureknock-downknockdownmalic enzymemembermitochondrialmitochondrial dysfunctionmitochondrial membraneneuroprotectionneuroprotectiveoverexpressoverexpressionoxidation reduction reactionoxidative damageoxidative injuryparticipant recruitmentpathophysiologypathwaypersonalized approachpolygenetic risk scorespolygenic risk scoreprecision approachprecision medicineprecision-based medicinepyruvic-malic carboxylaseresponseretinal ganglionrisk allelerisk generisk genotyperisk locirisk locusrisk stratificationrisk variantskillssocial rolestratify riskstudy designtailored approachtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthioredoxin reductase 2vascularvision lossvisual losswhole genome association analysiswhole genome association study
Description preview
The NIH Precision Medicine Initiative was launched in 2015 with the goal of improving disease treatment and
prevention based on understanding of genes, environment, and lifestyle. As a first step towards this goal,
genome-wide association studies (GWAS), funded in part by the NIH, have identified 127 genes associated
with risk for developing…
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