grant
Clinical and Biochemical Features of Metabolic Dysregulation in Formerly Preterm Children
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 15 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20250-11 years old12 year old12 years of age21+ years old3-10CAMCF-IAdultAdult HumanAgeAir MovementsB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BiochemicalBiochemical MarkersBiologicalBiological MarkersBlood SampleBlood VesselsBlood specimenBronchopulmonary DysplasiaCXCL8CardiopulmonaryCaringCharacteristicsChildChild YouthChildhoodChildren (0-21)ChronicChronic DiseaseChronic IllnessChronologic Fetal MaturityCirculationClassificationClinicalCor pulmonaleDataDefectDiabetes MellitusDiffusionDiseaseDisorderDysfunctionEarly InterventionEchocardiogramEchocardiographyEnergy ExpenditureEnergy MetabolismEthnic OriginEthnicityExerciseExercise ToleranceF2-IsoprostanesFamilyFetal AgeFoundationsFunctional disorderFutureGCP1Gestational AgeHPGFHealthHepatocyte-Stimulating FactorHumanHumulin RHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL-8IL6 ProteinIL8IL8 geneImmune responseInfantInflammationInflammatoryInsulinInsulin ResistanceInterleukin-6K60LeftLinkLive BirthLongitudinal StudiesLung Function TestsMGI-2MeasurementMeasuresMedicalMetabolicMetabolic DiseasesMetabolic DisorderMetabolic dysfunctionMetabolic syndromeModelingModern ManModificationMolecularMolecular FingerprintingMolecular ProfilingMonitorMorbidityMorbidity - disease rateMyeloid Differentiation-Inducing ProteinNational Institutes of HealthNovolin RObesityObstructive Lung DiseasesOutcomeOxidative StressPBMCPeripheral Blood Mononuclear CellPhenotypePhysiopathologyPlasmacytoma Growth FactorPrecision carePredispositionPremature BirthPremature InfantPrematurely deliveringPreterm BirthPrevalenceProductivityPublishingPulmonary Heart DiseasePulmonary Heart DisorderPulmonary HypertensionPulmonary function testsRNA SeqRNA sequencingRNAseqRaceRacesRegular InsulinResearch InfrastructureRight Ventricular FunctionRight ventricular strainRiskSCYB8School-Age PopulationSocial InteractionStressSurvivorsSusceptibilitySystematicsSystemic hypertensionTSG-1TestingThesaurismosisTransthoracic EchocardiographyUnited States National Institutes of HealthVariantVariationVascular DiseasesVascular DisorderVentricularWalkingactigraphactigraphyadiposityadult youthadulthoodage 12 yearsagesair flowairflowairflow limitationairflow obstructionairway limitationairway obstructionb-ENAPbio-markersbiologicbiologic markerbiomarkerblood vessel disorderburden of diseaseburden of illnesscardiac MRIcardiac magnetic resonance imagingcardiopulmonary diseasecardiopulmonary disorderchronic disorderchronic lung disease in infantschronic lung disease in neonatal infantschronic lung disease in neonateschronic lung disease in newbornschronic lung disease in prematuritychronic lung disease in preterm infantschronic lung disease of infancychronic lung disease of prematurityclinical infrastructureclinical phenotypecohortcorpulencediabetesdifferential expressiondifferentially expresseddiffuseddiffusesdiffusingdiffusionsdisease burdenearly childhoodendophenotypegene signaturesgenetic signatureheart sonographyhost responsehypertensiveimmune system responseimmunoresponseimpaired pulmonary vascularizationindividualized careindividualized patient careinfant chronic lung diseaseinfants born prematureinfants born prematurelyinfants with chronic lung diseaseinsightinsulin resistantinsulin toleranceinterferon beta 2kidslife spanlifespanlong-term studylongitudinal outcome studieslung vascular diseasemetabolism disordermolecular profilemolecular signatureneonatal chronic lung diseasenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnewborn chronic lung diseasenovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetobstructed airflowobstructed airwayobstructive pulmonary diseasespathophysiologypediatricperipheral bloodpersonalized carepersonalized patient carepost-prematurity respiratory diseaseprematurepremature babypremature childbirthpremature deliverypremature infant humanprematuritypreterm babypreterm deliverypreterm infantpreterm infant humanpreterm infants with chronic lung diseaseprimary outcomepulmonarypulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vasculopathyracialracial backgroundracial originrespiratoryrespiratory airway obstructionright heart strainright sided heart strainright ventricle strainright ventricular load stressright ventricular stressschool agesexsocial health determinantssocial metricssociometricssystemic inflammationsystemic inflammatory responsetranscriptional differencestranscriptome sequencingtranscriptomic sequencingtwelve year oldtwelve years of agevascularvascular dysfunctionvasculopathyyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
In the US, ~100,000 babies are born premature at <34 weeks gestational age (GA) each year, or ~2.7% of all
live births. While infant preterm respiratory, pulmonary vascular, and systemic vascular diseases are common
among those born preterm, many become asymptomatic in early childhood. Yet, emerging data point to
subclinical abnormalities among…
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