grant
Classification of tumors using whole-genome methylation profiling
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AccelerationAccuracy of DiagnosisAdoptionBrain NeoplasiaBrain NeoplasmsBrain TumorsCNS TumorCNS neoplasmCancer BurdenCancer DetectionCancersCentral Nervous System NeoplasmsCentral Nervous System TumorsClassificationClinicalClinical PathologyDNA AlterationDNA MethylationDNA Sequence AlterationDNA methylation profilingDNA mutationDNA seqDNA sequencingDNAseqDataDevelopmentDiagnosisDiagnosticFosteringGene FusionGenetic AlterationGenetic ChangeGenetic defectGenetic mutationGoalsHistopathologyMalignant NeoplasmsMalignant TumorMethodsMethyl-SeqMethylSeqMethylationMethylation sequencingMissionModalityModernizationMolecularMutationNCI OrganizationNGS MethodNGS systemNational Cancer BurdenNational Cancer InstituteNon-Polyadenylated RNAPatient CarePatient Care DeliveryPatientsPublishingRNARNA Gene ProductsReproducibilityResolutionRibonucleic AcidRoleSequence AlterationSeriesSystematicsTherapeuticUpdateanti-cancer researchcancer researchcare for patientscare of patientscaring for patientsclinical practicedevelopmentaldiagnostic accuracydiagnostic criteriadiagnostic platformdiagnostic systemdiagnostic tooldisparity eliminationdisparity in caredisparity in health careeliminate disparitieseliminating disparitiesentire genomefull genomegenome mutationgenomic alterationhealth care disparityhealth care inequalityhealth care inequityimprovedindividual patientinnovateinnovationinnovativeinterdisciplinary collaborationmalignancymolecular diagnosticsneoplasm/cancerneuro-oncologyneurooncologyneuropathologicneuropathologicalneuropathologynext gen sequencingnext generation sequencingnextgen sequencingpersonalized diagnosispersonalized diagnosticsprecise diagnosticsprecision diagnosticsprogramsresolutionssocial rolestandard of caretransdisciplinary collaborationtumortumor of the central nervous systemtumors in the braintumors in the central nervous systemwhole genome
Description preview
The classification of Central Nervous System (CNS) tumors is undergoing a significant transformation, driven by the adoption of biologically grounded, objective diagnostic tools. A major shift began with the 2016 WHO update, which formally introduced molecular features, such as specific genetic alterations, into the diagnostic definitions of tumor…
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