grant
Clarifying the interplay between herpesvirus infection and reactivation, immune responses, APOE genotype, and development of tau-pathology
Organization HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTHLocation BOSTON, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD pathologyAD related dementiaADRDAPOEAccelerationActive Follow-upAdultAdult HumanAffectAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's diagnosisAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease diagnosisAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAnti-viral AgentsAnti-viral TherapyApo-EApoE proteinApolipoprotein EAssayBacteriaBacterial InfectionsBehavioralBioassayBiological AssayBiological MarkersCNS Nervous SystemCNS infectionCausalityCentral Nervous SystemCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderChickenpox VirusCognitiveComplexDataDevelopmentDiseaseDisorderEtiologyGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGenotypeGoalsHHV-3HHV3HSV-1HSV1HabitsHealthHerpes SimplexHerpes Simplex InfectionsHerpes Simplex Type 1Herpes Simplex Virus 1Herpes Simplex Virus Type 1Herpes ZosterHerpes infectionHerpes simplex diseaseHerpes zoster VirusHerpes zoster diseaseHerpesviridaeHerpesviridae InfectionsHerpesviridae diseaseHerpesvirus 1Herpesvirus InfectionsHerpesvirus Type 3Herpesvirus hominis diseaseHerpesvirus varicellaeHerpesvirusesHumanHumoral ImmunitiesImmune PrecipitationImmune responseImmunoprecipitationIndividualInfectionInherited PredispositionInherited SusceptibilityInvestigationLaboratoriesLife StyleLifestyleLinkLong-term cohortLongitudinal StudiesLongitudinal cohortLuciferase ImmunologicLuciferasesMT-bound tauMapsMeasuresMediatingMedicalModern ManNeuraxisNucleic AcidsNurses' Health StudyOcular Herpes zoster VirusPathologicPathologyPhasePredispositionPreventative strategyPrevention strategyPreventive strategyPrimary Senile Degenerative DementiaProcessProtein ArrayProteinsResearch ResourcesResourcesRiskRisk FactorsRisk ReductionRoleSamplingShinglesSourceSusceptibilitySymptomsSystemTauopathiesVZ VirusVaccinationVaccinesVaricella-Zoster VirusViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirusVirus DiseasesWomanZonaZosterabeta depositionactive followupadulthoodagesalzheimer riskamyloid beta depositionamyloid β depositionanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsantibody-based immunityaβ depositionbacteria infectionbacterial diseasebio-markersbiologic markerbiomarkercase controlcase-controlledcausationdesigndesigningdevelopmentaldietarydisease causationfollow upfollow-upfollowed upfollowupgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedherpes simplex iherpes simplex virus 1 infectionherpes simplex virus infectionherpes simplex-1herpes virusherpes zonahigh riskhost responsehuman viromeimmune system responseimmunoresponseimprovedlife-style factorlifestyle factorslong-term studylongitudinal outcome studiesmicrobialmicrotubule bound taumicrotubule-bound tauneuropathologic tauneuropathological taunew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approacholder adultolder adulthoodp-taup-τpatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasephospho-tauphospho-τphosphorylated taupost-translational modification of tauposttranslational modification of taupre-clinicalpreclinicalprimary degenerative dementiareduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk-reducingsample archivesenile dementia of the Alzheimer typesocial roletautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytreatment strategyviral infectionviral infectious disease treatmentvirus infectionvirus proteinvirus-induced diseaseτ Proteinsτ phosphorylation
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PROJECT SUMMARY/ABSTRACT
The role of microbial infections in triggering Alzheimer's disease (AD) has gained increasing support. In several
studies, specific viruses and bacteria capable of infecting the central nervous system (CNS) were found more
frequently in AD patients, and recent discoveries link infections to key aspects of AD pathology.…
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