grant
Circulating and Brain Lipidomics, Cognition and Dementia
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 30 Sept 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years old9-hexadecenoic acidAD dementiaAcidsAdultAdult HumanAfrican ancestryAfrican descentAged 65 and OverAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's brainAlzheimer's diagnosisAlzheimer's disease brainAlzheimer's disease diagnosisAlzheimer's disease patientAlzheimer's disease riskAlzheimer's patientAlzheimers DementiaAmentiaAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAutopsyAβBlood PlasmaBrainBrain Nervous SystemCell BodyCellsCharacteristicsCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCohort StudiesConcurrent StudiesDementiaDepositDepositionDietary FactorsDisturbance in cognitionDocosahexaenoateDocosahexaenoic AcidsDocosahexenoic AcidsDrugsEicosapentaenoic AcidEncephalonEuropean ancestryFatty AcidsFutureHealth TransitionHexadecanoic AcidImpaired cognitionInterventionLipidsMT-bound tauMeasuresMedicationMethodsN-3 polyunsaturated fatty acidNerve DegenerationNeuritic PlaquesNeuron DegenerationOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega3OutcomePalmitic AcidsParticipantPathway interactionsPatientsPharmaceutical PreparationsPhenotypePhysical activityPlasmaPlasma SerumPreventionPrimary Senile Degenerative DementiaProspective cohortReportingResearchResearch ResourcesResearch SpecimenResourcesReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRisk ReductionSamplingSaturated Fatty AcidsSenile PlaquesSpecimenTechnologyTimnodonic AcidTobacco ConsumptionTobacco useUniversitiesWomana beta peptideabetaabove age 65adipogenesisadulthoodafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65aging delayalzheimer riskamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinattenuate agingaβ plaquesbeta amyloid fibrilbrain researchcardiovascular healthcognitive dysfunctioncognitive losscohortcored plaquedecelerate agingdelay age relateddementia riskdiffuse plaquedrug/agenteicosapentanoic acidhuman old age (65+)insightlipid biosynthesislipidomicslipogenesismalleable riskmenmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmodifiable riskn-3 Fatty Acidsn-3 PUFAnecropsyneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnew technologynovelnovel technologiesolder adultolder adulthoodomega-3omega-3sover 65 yearspalmitoleic acidpathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepause agingpostmortempostpone age relatedpreventpreventingprimary degenerative dementiaprospectivereduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskretards agingrisk factor for dementiarisk for dementiarisk-reducingsenile dementia of the Alzheimer typeslow agingslow down agingslow the rate of agingsocietal costssoluble amyloid precursor proteintautau Proteinstau factortobacco product useτ Proteins≥65 years
Description preview
Decline in cognition and the onset of Alzheimer’s disease (AD) and dementia impose a devastating personal
and interpersonal burden with huge societal costs. To provide insights into new mechanisms and identify
novel targets to prevent AD, dementia and cognition decline, we propose a comprehensive study of plasma
and brain lipidomics species and…
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