grant
Circularization of RNA to improve the durability of the vaccine immune response
Organization UNIVERSITY OF TEXAS MED BR GALVESTONLocation GALVESTON, UNITED STATESPosted 5 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20267S Gamma GlobulinAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdjuvantAffectAffinityAndes VirusAntibodiesAntibody ResponseAntibody SpecificityAntigensB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBNT 162b2BNT162b2Blood Plasma CellBlood SerumBunyaviralesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCOVID-19CV-19CardiopulmonaryCase Fatality RatesCell BodyCellsCoronavirus Infectious Disease 2019CricetinaeDataDevelopmentDisease OutbreaksDoseDropsEnvironmentEpitope MappingExonucleaseFDA approvedFour Corners VirusFour Corners hantavirusGerminal CenterHIVHamstersHamsters MammalsHantavirusHumanHuman Immunodeficiency VirusesIgGImmuneImmune responseImmunesImmunochemical ImmunologicImmunoglobulin GImmunologicImmunologicalImmunologicallyImmunologicsIn VitroIndividualInjectionsInnate Immune ResponseInnate Immune SystemInvestigationKO miceKineticsKnock-out MiceKnockout MiceLAV-HTLV-IIILYT3LigaseLigase GeneLymphadenopathy-Associated VirusMediatingMemory B CellMemory B-LymphocyteMessenger RNAMiceMice MammalsMissionModelingModern ManModificationMolecularMuerto Canyon VirusMurineMusNational Institutes of HealthNeutralization TestsNon-Polyadenylated RNANull MouseOrthohantavirusesOsmosisOutbreaksPfizer covid19 vaccinePfizer-BioNTech COVID-19 vaccinePfizer-BioNTech coronavirus disease 2019 vaccinePfizer/BioNTech vaccinePlasma CellsPlasmacytesPlayPre-Clinical ModelPreclinical ModelsProteinsPseudouridinePumpRNARNA Gene ProductsRNA vaccineRNA-based vaccineReceptor ProteinResistanceRibonucleic AcidRoleSerumSin Nombre hantavirusSin Nombre virusSiteSpecificityStructure of germinal center of lymph nodeSyndromeSynthetasesT cell responseT4 CellsT4 LymphocytesTestingTimeTransfectionTranslationsTransmissionUnited States National Institutes of HealthVaccinationVaccinesViral DiseasesVirusVirus DiseasesVirus-HIVadaptive immune responseantibody neutralization testcircular RNAclinical developmentclosed circular RNAcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19cytokinedelivery vectordelivery vehicledevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalemerging pathogenepidemic concernepidemic potentialepidemic riskepidemic threatglobal gene expressionglobal transcription profilehost responseimmune response to vaccinationimmune response to vaccinesimmune system responseimmunogenimmunoresponseimprovedin vivoinnovateinnovationinnovativelipid based nanoparticlelipid nanoparticlemRNAmRNA vaccinemRNA-based vaccinenew pathogennovel pathogenoligoadenylatepandemic concernpandemic potentialpandemic riskpandemic threatpathogenplasmocyteprotein activationprotein expressionprotein kinase Rprototypereceptorreceptor bindingreceptor boundresistantresponsesocial roletranscriptometranslationtransmission processvaccine associated immune responsevaccine developmentvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine platformvaccine responsevaccine responsivenessvaccine-induced responseviral infectionvirus infectionvirus-induced disease
Description preview
ABSTRACT
mRNA vaccines are one of the most promising vaccine platforms available to rapidly deploy in response
to emerging viral infections. However, the duration of the protective antibody response induced by these vaccines
is limited, even after multiple vaccine doses. The rapid decay of the antibody response to mRNA vaccines
necessitates…
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