grant
Circuit Mechanisms of Retrospective Memory-Linking
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 3 Dec 2019Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026Ammon HornAnimalsAnxietyAutomobile DrivingBehaviorBehavioralBrainBrain Nervous SystemCalciumCornu AmmonisDangerousnessDataDorsalElectrophysiologyElectrophysiology (science)EmotionalEncephalonEventFearFrightFutureGoalsHippocampusImageImmediate-Early GenesImmobilizationIn vivo two-photon calcium imagingIndividualLearningLinkMemoryMemory DeficitMemory impairmentMethodsMiceMice MammalsMurineMusNREMNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyPlayRestRoleSleepStimulusSystemTestingTimeTraumaUpdateWorkdrivingelectrophysiologicalexperiencehippocampalimagingimprovedin vivoin vivo calcium imaginginsightmemory consolidationmemory dysfunctionmemory encodingmemory recallneuralneuronalnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnoveloptogeneticsorthopedic freezingpreventpreventingrapid eye movementsocial role
Description preview
Project Summary
The central goal of this proposal is to investigate the circuit mechanisms of memory linking, specifically
how aversive memories retrospectively update and link to past neutral memories during post-encoding offline
periods to influence future behavior, such as avoiding dangerous situations. Memories are encoded in a sparse
neural…
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