grant
Chronic Pain and Risk of Alzheimer's-Related Neurodegeneration
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 15 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAD associated neurodegenerationAD dementiaAD neurodegenerationActive Follow-upAddressAdultAdult HumanAffectAgeAgingAlzheimer Type DementiaAlzheimer associated neurodegenerationAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer related neurodegenerationAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's brainAlzheimer's disease associated neurodegenerationAlzheimer's disease brainAlzheimer's disease related neurodegenerationAlzheimer's disease riskAlzheimers DementiaAmentiaAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAmyloidosisAnimal ModelAnimal Models and Related StudiesAnimalsAutomobile DrivingAβBiologicalBiological FunctionBiological MarkersBiological ProcessBiologyBrainBrain Nervous SystemBrain regionCaliforniaCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesChronicCo(beta)-cyano-7''-(2-methyl)adeninylcobamideCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalCompetenceComplementComplement ProteinsDataData SetDementiaDiagnosisDisturbance in cognitionEarly DiagnosisEducationEducational aspectsEmotional DepressionEncephalonEnvironmentFemaleFramingham Heart StudyGoalsHEAL InitiativeHealthHealth Care CostsHealth CostsHelping End Addiction Long-termHelping to End Addiction Long-termHumanImpaired cognitionInvestigatorsK-AwardsK-Series Research Career ProgramsKnowledgeLightLinkLocus CoeruleusMT-bound tauMeasuresMemoryMentorsModern ManNIAAANational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthNerve DegenerationNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeuron DegenerationNeuronal InjuryNucleus Pigmentosus PontisPainPain ControlPain TherapyPain managementPainfulPathologicPersonsPhotoradiationPredispositionPreventative interventionPrimary Senile Degenerative DementiaProteinsPsychiatryRaceRacesResearchResearch Career ProgramResearch PersonnelResearchersRetrospective StudiesRiskRisk FactorsRisk ReductionSamplingStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationSusceptibilityThickThicknessTrainingTraining ActivityTwin StudiesUnited StatesUnited States National Institutes of HealthUniversitiesViet NamVietnamWorka beta peptideabetaactive followupadulthoodagesalzheimer riskamyloid betaamyloid diseaseamyloid-b proteinbeta amyloid fibrilbio-markersbiologicbiologic markerbiomarkerblue nucleusbrain volumecareer developmentchronic paincognitive dysfunctioncognitive losscomplementationdementia riskdepression symptomdepressivedepressive symptomsdrivingearly detectionethnic minorityfactor Afollow upfollow-upfollowed upfollowuphigh riskimprovedinnovateinnovationinnovativeinterestintervention for preventionlack of physical activitylater in lifelater lifelocus ceruleus structuremalleable riskmicrotubule bound taumicrotubule-bound taumid lifemid-lifemiddle agemiddle agedmidlifemild cognitive disordermild cognitive impairmentmodel of animalmodifiable riskmultidisciplinarymultimorbiditymultiple chronic conditionsmultiple data setsmultiple datasetsnerve cell deathnerve cell lossneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurofilamentneuroimagingneurological degenerationneurological imagingneuron cell deathneuron cell lossneuron deathneuron injuryneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossnovelolder adultolder adulthoodopiate consumptionopiate drug useopiate intakeopiate useopioid consumptionopioid drug useopioid intakeopioid usepain interventionpain treatmentphysical inactivityprevention interventionpreventional intervention strategypreventive interventionprimary degenerative dementiaprogramsracialracial backgroundracial minorityracial originreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskreligious order studyrisk factor for dementiarisk for dementiarisk-reducingsecondary analysissenile dementia of the Alzheimer typesexskillssoluble amyloid precursor proteinstatistical analysistautau Proteinstau factortraining moduleτ Proteins♀
Description preview
7. PROJECT SUMMARY
The long-term goal of the proposed career development award is to provide the training necessary to develop
an independent research program investigating how chronic pain is related to dementia risk. Such research is
timely given recent links between chronic pain and a doubled risk of dementia due to Alzheimer's disease
(AD).…
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