grant
Chronic Murine Cerebral Mycosis: Pathogenesis, Neuroimmune Response, and Relevance to Alzheimer's Disease
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Jul 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202616S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqAD brainAD dementiaAD modelAD preventionAPOEAPOE e4APOE-ε4APOEε4AffectAlimentary CanalAllelesAllelomorphsAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's brainAlzheimer's disease brainAlzheimer's disease modelAlzheimer's disease therapeuticAlzheimer's precursor proteinAlzheimer's therapeuticAlzheimers DementiaAmentiaAmyloid (Aβ) plaquesAmyloid A4 Protein PrecursorAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid Protein PrecursorAmyloid beta-ProteinAmyloid beta-Protein PrecursorAmyloid βAmyloid β-PeptideAmyloid β-ProteinAmyloid β-Protein PrecursorAnxietyApo-EApoE proteinApolipoprotein EAspartic EndopeptidasesAspartic ProteinasesAspartyl ProteasesAspartyl ProteinasesAβBBB penetrationBacteriaBacterial AdhesinsBehaviorBiological Response ModifiersBiomodulatorsBlocking AntibodiesBlood - brain barrier anatomyBlood CirculationBlood-Brain BarrierBloodstreamBody TissuesBrainBrain Nervous SystemC albicansC. albicansC.albicansC57BL/6 MouseCandida albicansCandidiasisCandidosisCarboxyl (Acid) ProteinasesCarboxylic ProteinasesCause of DeathCell BodyCellsCerebrumCharacteristicsChronicColiform BacilliComplementComplement ProteinsDataDementiaDepositDepositionDevelopmentDiagnosisDigestive TractDiseaseDisorderDoseELISAEncephalonEnteric BacteriaEnteritisEnterobacteriaEnterobacteriaceaeEnzyme-Linked Immunosorbent AssayFearFilamentFrightGI TractGI colonizationGastric InflammationGastritisGastrointestinal TractGastrointestinal tract structureGenesGenotypeGenus staphylococcusGranulomaGranulomatous LesionHarvestHemato-Encephalic BarrierHistologicHistologicallyHistologyHumanIFNImmuneImmune EvasionImmune MediatorsImmune Mediators/ModulatorsImmune responseImmunesImmunoblottingInfectionInflammatoryInterferonsIntestinalIntestinesIntravenousInvadedLinkLyticMemory DeficitMemory LossMemory impairmentMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModelingModern ManMoniliasisMonitorMorphologyMurineMusNeoplasm MetastasisNeuritic PlaquesNeurofibrillary TanglesNeuroimmuneNeuroimmune MechanismsNeuroimmune ProcessesNeuroimmunomodulationNeurologic DysfunctionsOralPathogenesisPathogenicityPathogenicity FactorsPathologicPeptidesPhysiologicPhysiologicalPrimary Senile Degenerative DementiaProtein CleavageProteolysisProteomePublic HealthPublishingRecurrenceRecurrentResearchRoleSamplingSecondary NeoplasmSecondary TumorSenile PlaquesSiteStaphylococcusStructureSurfaceTauopathiesTestingTherapeutic FungicidesTissuesToxinTransgenic MiceTransmissionUnited StatesVirulence FactorsWestern BlottingWestern ImmunoblottingYeastsa beta peptideabetaadhesinalimentary tractalzheimer modelamyloid betaamyloid beta plaqueamyloid precursor proteinamyloid-b plaqueamyloid-b proteinanti-fungalanti-fungal agentsanti-fungal drugapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4aspartate proteaseaspartic proteaseaβ plaquesbacteria in the gutbehavior testbehavioral testbeta amyloid fibrilbioplexblood-brain barrier penetrationbloodbrain barrierbloodbrain barrier penetrationbowelbowel inflammationbrain sizecancer metastasiscandidaemiacandidemiacerebralcognitive functioncomplementationcored plaquecytokinedevelopmentaldiffuse plaquedigestive canaldisease phenotypeenzyme linked immunoassayfecal samplefungusgastrointestinal tract colonizationgut bacteriagut colonizationgut inflammationhost responseimmune evasiveimmune system responseimmunoresponseinflamed bowelinflamed gutinflamed intestineintestinal colonizationintestinal inflammationintravenous administrationmemory declinememory dysfunctionmigrationmouse modelmurine modelmutantneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological dysfunctionneuropathologic tauneuropathological taunovelp-taup-τphospho-tauphospho-τphosphorylated taupost-translational modification of tauposttranslational modification of taupreventpreventingprimary degenerative dementiaprotein blottingresponsesenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinstool samplestool specimensuccesssynthetic polymer Bioplextangletau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytranslational modeltransmission processtumor cell metastasisyeast infectionτ phosphorylation
Description preview
Alzheimer’s Disease (AD) is the sixth leading cause of death in the United States and the only cause of death in
the top ten that cannot be effectively prevented, treated, or cured. Recent evidence suggests that AD may be
linked to fungal brain infections. To rigorously study this possibility, we established a model of cerebral mycosis
by…
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