grant
Chromosome Dynamics and Evolution
Organization NATIONAL HEART, LUNG, AND BLOOD INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025AURKBAffectAllelesAllelomorphsAnaphaseAneuploidAneuploidyAnimalsBUB1BUB1 geneBUBR1 GeneBehaviorBiologicalBiologyCannot achieve a pregnancyCell BodyCell divisionCellsCentromereChromosome ArmChromosome SegregationChromosomesDefectDifficulty conceivingDiploidDiploidyDrosophilaDrosophila genusElementsEukaryotaEukaryoteEvolutionFailureFecundabilityFecundityFemaleFemale sterilityFertilityFertility DisordersGametesGene FrequencyGenesGeneticGenetic DiseasesGenomeGerm CellsGerm-Line CellsGoalsHaploidHaploidyHumanHybridsIndian CornInfertilityKinesinKinetochoresLawsLeadLinkM PhaseMAD3L GeneMaizeMammaliaMammalsMeiosisMiceMice MammalsMicro-tubuleMicrotubulesMitosisMitosis StageMitotic AnaphaseModern ManMolecularMurineMusMus domesticusMus musculus domesticusOocytesOvocytesParentsPb elementPeromyscusPhenotypePisum sativumPlayPopulationProcessProductionProteinsRecurrenceRecurrentRegulationReportingReproductionReproductive CellsRestRoleSelfish GenesSex CellSexual ReproductionSideSterilitySystemTimeTransmissionWorkadvanced maternal ageadvanced reproductive ageallelic frequencyaurora B kinasebiologicchromosome divisioncohesincohesioneggexperimentexperimental researchexperimental studyexperimentsfertility cessationfertility defectfertility lossfitnessfruit flygenetic conditiongenetic disordergenetic elementhBUB1 Geneheavy metal Pbheavy metal leadinfertileinitial cellmeioticmouse modelmurine modelnext generationparentpeapreventpreventingreproductiveresponsesegregationselfish genetic elementsexual cellsocial rolesterilesterility of femalestransmission processupstream kinase♀
Description preview
- Mechanisms of non-Mendelian segregation through female meiosis
To understand how meiotic drive elements achieve non-Mendelian segregation, we currently focus on selfish centromeres in mice. Expanded centromeric satellite repeats can violate Mendel's law of segregation by preferentially segregating to the egg cell. In mice, these selfish…
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