grant
Chromatin structure and dynamics
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Basal Transcription FactorBasal transcription factor genesBindingCalorimetryCancersCell BodyCellsChaperoneChromatinChromatin StructureCryo-electron MicroscopyCryoelectron MicroscopyDNADeoxyribonucleic AcidDiseaseDisorderElectron CryomicroscopyEukaryotaEukaryoteFRETFluorescence Resonance Energy TransferFörster Resonance Energy TransferGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenomeHMG DomainHMG ProteinsHP-1 proteinHigh Mobility Group DomainHigh Mobility Group ProteinsHistonesKinetochoresMalignant NeoplasmsMalignant TumorMolecular ChaperonesMolecular InteractionNuclear Magnetic ResonanceNucleosomesPlayProcessProteinsRoleSingle Crystal DiffractionStructureTechniquesTitrationsTranscription Factor Proto-OncogeneTranscription factor genesX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographycellular developmentcryo-EMcryoEMcryogenic electron microscopygene functionheterochromatin protein 1heterochromatin-specific nonhistone chromosomal protein HP-1interestmalignancyneoplasm/cancersocial roletranscription factor
Description preview
In this fiscal year, we utilize a range of cutting-edge scientific techniques, including nuclear magnetic resonance (NMR), X-ray crystallography, cryo-electron microscopy (Cryo-EM), isothermal titration calorimetry (ITC), and Förster resonance energy transfer (FRET). We focuse on the following molecular interactions, including (i) how pioneer…
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