grant
Chromatin Architecture Regulatory Mechanisms in Pathogenesis of B-Cell Lymphomas
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 12 Jun 2019Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DArchitectureAutomobile DrivingB blood cellsB cellB cellsB lymphomaB-Cell LymphomasB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBiochemicalBiologicalBiologyBlood Plasma CellBody TissuesCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCell BodyCell LineageCellsCessation of lifeChromatinClonal EvolutionComplexDLBCLDNA mutationDataDeathDevelopmentDiffuse Large B-Cell LymphomaElementsEndowmentEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFundingGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenome InstabilityGenomic InstabilityGenomicsGerminal CenterGerminoblastic SarcomaGerminoblastomaGrantHistonesHistoryIg Somatic HypermutationImmune responseImmunoglobulin Somatic HypermutationLesionLymphomaLymphoma cellMalignantMalignant - descriptorMalignant CellMalignant LymphomaMalignant NeoplasmsMalignant TumorMediatingMemory B CellMemory B-LymphocyteMethodsMutationNatureNormal CellOCT2OTF2OncogenicPOU2F2POU2F2 genePathogenesisPatientsPhenotypePhysiologicPhysiologicalPlasma CellsPlasmacytesPlayProcessProgenitor CellsPropertyRNA ExpressionReactionRecording of previous eventsRecurrenceRecurrentRegulator GenesRegulatory ElementReticulolymphosarcomaRoleShapesSpecific qualifier valueSpecificitySpecifiedStem Cell likeStructureStructure of germinal center of lymph nodeTechnologyTherapeuticTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional Regulatory ElementsWorkbiologiccancer cellcancer progressioncell typeclustered regularly interspaced short palindromic repeats screencohesindevelopmentaldrivingdynamic systemdynamical systemepigeneticallyfitnessgene networkgenetic predictorsgenetic trans acting elementgenome mutationhistorieshost responseimmune system responseimmunoresponseinsightlarge cell Diffuse non-Hodgkin's lymphomamalignancymultiomicsmultiple omicsmutantneoplasm progressionneoplasm/cancerneoplastic progressionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypanomicsplasmocyteprogenitor capacityprogenitor cell geneprogenitor cell likeprogenitor geneprogenitor-likeprogramspromoterpromotorregulatory generesponseself-renewself-renewalsocial rolesomatic hypermutationspatial and temporalspatial temporalspatiotemporalstem cell characteristicsstem cell genesstem cellsstem-likestemnesstherapeutic targetthree dimensionaltrans acting elementtranscription factortumortumor progressionvirtual
Description preview
PROJECT 2: PROJECT SUMMARY
Cell fate transitions and cancer phenotypes depend upon the establishment of specific transcriptional programs.
The dynamic folding of chromatin acts as a key regulatory layer of gene expression and cell identity by allowing
select chromatin regions to facilitate transcription factor (TF) action, spatiotemporal…
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