grant
Cholesterol Regulation Through Retriever-Dependent LDL Receptor Recycling
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 May 2025Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025ASCVDActinsAddressAffectAnimal ModelAnimal Models and Related StudiesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAutoregulationBackBindingBiochemicalBiochemistryBiological ChemistryBlood PlasmaCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell membraneCell modelCell surfaceCellsCellular biologyCellular modelCholesterolCholesterol HomeostasisCirculationComplexCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic DomainCytoplasmic MembraneCytoplasmic TailDNA mutationDistantDorsumElectron CryomicroscopyEndosomesEquilibriumFoundationsGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisHeart VascularHepatic CellsHepatic Parenchymal CellHepatocyteHomeostasisHumanHypercholesteremiaImpairmentIndividualInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsKO miceKnock-out MiceKnockout MiceKnowledgeLDLLDL CholesterolLDL Cholesterol LipoproteinsLDL LipoproteinsLDL ReceptorsLDLR geneLabelLigandsLinkLipoprotein LDL ReceptorsLiverLiver CellsLow Density Lipoprotein CholesterolLow Density Lipoprotein ReceptorLow-Density LipoproteinsMediatingMiceMice MammalsMissionModelingModern ManMolecularMolecular InteractionMurineMusMutagenesisMutagenesis Molecular BiologyMutationNHLBINational Heart, Lung, and Blood InstituteNull MousePathway interactionsPhosphatidyl InositolPhosphatidylinositolsPhosphoinositidesPhysiologicPhysiologicalPhysiological HomeostasisPlasmaPlasma MembranePlasma SerumPlayPolymersPrebeta-LipoproteinsProcessProtein FamilyProteinsProteomicsPtdInsPublishingReceptor ProteinReceptosomesRecyclingRegulationResolutionReticuloendothelial System, Serum, PlasmaRisk FactorsRoleStructural ModelsStructureSurfaceTherapeuticVLDLVLDL LipoproteinsValidationVery low density lipoproteinWiskott-Aldrich syndrome proteinWorkatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebalancebalance functionbeta-Lipoprotein Cholesterolbeta-Lipoproteinsbiochemical modelcardiovascular disordercardiovascular healthcell biologycholesterol metabolismcirculatory systemclinical significanceclinically significantconditional knock-outconditional knockoutcryo-EMcryoEMcryogenic electron microscopydensityendosome membranegenome mutationhepatic body systemhepatic organ systemhigh blood cholesterolhypercholesterolemiain vivoin vivo Modelinsightmembermodel of animalpathwayplasmalemmapolymerpolymericpolymerizationpreventpreventingprotein complexprotein homeostasisproteostasisreceptorreceptor recyclingresolutionssocial rolesorting nexinsstructural biologysuccesstraffickingvalidations
Description preview
PROJECT SUMMARY
Elevated plasma LDL cholesterol is a potent risk factor for atherosclerosis and cardiovascular
complications. LDL is cleared from circulation by LDL receptors (LDLR). Importantly, the balance
between internalization, recycling, and intracellular degradation of LDLR is critical in determining surface
expression of LDLR, LDL…
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