grant
Cholesterol Metabolism in Regulatory T cell Function
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026Activities of Daily LivingActivities of everyday lifeAddressAdoptive Cellular ImmunotherapyAdoptive ImmunotherapyAdoptive TransferAffectAffinityAntigensAutoantigensAutoimmuneAutoimmune DiabetesAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologousAutologous AntigensAutoregulationB9 endocrine pancreasBasal Transcription FactorBasal transcription factor genesBindingBody TissuesBrittle Diabetes MellitusCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCancersCardiac DiseasesCardiac DisordersCell BodyCell FunctionCell Membrane Lipid RaftsCell Membrane LipidsCell PhysiologyCell ProcessCell TherapyCell membraneCellsCellular FunctionCellular PhysiologyCellular ProcessChIP SequencingChIP-seqChIPseqCholesterolCholesterol HomeostasisCo-StimulatorCostimulatorCytoplasmic MembraneDataData AnalysesData AnalysisDevelopmentEndocrine PancreasEpidermal Thymocyte Activating FactorExhibitsFOXP3FOXP3 geneForkhead Box P3General Transcription Factor GeneGeneral Transcription FactorsGenesHeart DiseasesHomeostasisHumulin RIDDMIL-2IL2 ProteinImmuneImmune Cell ActivationImmune responseImmunesImmunologic ModelImmunological ModelsInflammatoryInsulinInsulin-Dependent Diabetes MellitusInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-2Interleukine 2Interleukine 2 PrecursorInterleukine IIIslands of LangerhansIslets of LangerhansJM2Juvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLDL ReceptorsLDLR geneLigandsLipoprotein LDL ReceptorsLow Density Lipoprotein ReceptorLymphocyte Mitogenic FactorMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant NeoplasmsMalignant TumorMeasurementMediatingMembraneMembrane LipidsMembrane MicrodomainsMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsMitogenic FactorModelingMolecular InteractionMurineMusNesidioblastsNovolin ROrganOutcomePancreatic IsletsPars endocrina pancreatisPathway interactionsPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPhysiological HomeostasisPlasma MembranePublishingReceptor ActivationReceptor SignalingRegular InsulinRegulationRegulatory ElementRegulatory PathwayRegulatory T-LymphocyteResearchRestRoleSCURFINSelf-AntigensSiteSourceSpecificitySphingolipid MicrodomainsSphingolipid-Cholesterol RaftsSubcellular ProcessSudden-Onset Diabetes MellitusSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell growth factorT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen Receptor SpecificityT-Cell Antigen ReceptorsT-Cell Growth FactorT-Cell ReceptorT-Cell Receptor SpecificityT-Cell Stimulating FactorT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyT1 DMT1 diabetesT1DT1DMT4 CellsT4 LymphocytesTeff cellTestingThesaurismosisThymocyte Stimulating FactorTissuesTranscription Factor Proto-OncogeneTranscription factor genesTregType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyadoptive cell immunotherapyautoimmune conditionautoimmune disorderautoimmunity diseasecell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapycholesterol metabolismchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingdaily living functiondaily living functionalitydata interpretationdevelopmentaleffector T cellextracellularfat metabolismfatty acid oxidationfunctional abilityfunctional capacityheart disorderhigh rewardhigh riskhost responseimmune activationimmune system responseimmunogenimmunoresponseimprovedin vivoinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabeteslipid metabolismlipid raftlipidomicsmalignancymembrane structuremetabolic profilemetabolism disordermetabolism measurementmetabolomicsmetabonomicsmouse modelmurine modelneoplasm/cancernoveloverexpressoverexpressionpMHCpathwayplasmalemmapreventpreventingregulatory T-cellssocial roletherapeutic T-cell platformthymus derived lymphocytetranscription factortype I diabetestype one diabetesuptake
Description preview
ABSTRACT
Increased Treg T cell receptor (TCR) signaling is correlated with increased Foxp3+ regulatory T cell (Treg)
function in organ specific autoimmunity. In the context of autoimmunity, both Tregs and autoimmune T cells
target similar self-antigens, potentially increasing competition for TCR ligands. We propose that Tregs possess…
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