grant
Chemical tools for developmental biology
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2018Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldALDHALDH1ALDH1 enzymeALDH1A2ALDH1A2 geneAblationAdultAdult HumanAldehyde Dehydrogenase 1 Family, Member A2 GeneBasal Transcription FactorBasal transcription factor genesBiologyBody TissuesBone Morphogenetic Protein GeneBone Morphogenetic ProteinsBrachydanio rerioBreast CancerCancersCell BodyCell DifferentiationCell Differentiation processCellsChemicalsChemistryClinical TreatmentColorectal CancerCytoplasmDanio rerioDevelopmentDevelopmental BiologyEnzyme GeneEnzymesErinaceidaeEvolutionGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI1GLI1 GeneGLI1 ProteinGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGlioblastomaGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrowthHedgehogsHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingIndividualIntestinalIntestinesIsoformsKnowledgeLightMale ContraceptionMale Contraceptive AgentsMale ContraceptivesMalignant Breast NeoplasmMalignant MelanomaMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMedulloblastomaMelanomaMitochondriaModelingMolecularMotor CellMotor NeuronsO elementO2 elementOncogenesisOncogenicOxygenPancreasPancreas CancerPancreaticPancreatic CancerPathway interactionsPatternPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellProgenitor CellsProtein EngineeringProtein IsoformsRALDH2 GeneReagentResearchRetinaldehyde-Specific Dehydrogenase Type 2RoleScienceSignal PathwaySignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSpecific qualifier valueSpecifiedSpermatogenesisStem Cell likeSystemTechnologyTissue GrowthTissuesTranscription Factor Proto-OncogeneTranscription factor genesTranslatingVisual ReceptorZebra DanioZebra FishZebrafishadulthoodaldehyde dehydrogenase 1aldehyde dehydrogenase 1A2aldehyde dehydrogenasesbone morphogenic proteinbowelcancer progressioncellular differentiationchemical synthesisclinical interventionclinical therapycontraceptive targetdevelopmentalempowermentgenetic protein engineeringgenetic technologyglioblastoma multiformeglioma associated oncogene 1glioma associated oncogene family zinc finger 1human diseaseinhibitorinnovateinnovationinnovativeinsightlater in lifelater lifemale antifertility drugmalignancymalignant breast tumormitochondrialmotoneuronmotor controlmultipotent cellneoplasm progressionneoplasm/cancerneoplastic progressionnovelontogenyoptogeneticspancreatic malignancypathwayprogenitor capacityprogenitor cell likeprogenitor-likeprogramsprotein designretinal dehydrogenase IIreverse geneticssmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolespongioblastoma multiformestem cell characteristicsstem cellsstem-likestemnesstooltranscription factortrial regimentrial treatmenttumor initiationtumor progressiontumorigenesisvoltage
Description preview
Developmental biology is now both a molecular and systems-level science. Forward- and reverse-genetic
technologies have identified individual genes that regulate tissue formation and contribute to their oncogenic
transformation later in life. High-throughput sequencing has revealed the “omic” features that differentiate cellular
states.…
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