grant
Chemical Strategies to Modulate Intercellular Bacterial Communication
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 May 2019Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026Acute DiseaseAddressAdvanced DevelopmentAreaAttenuatedAwarenessBacteriaBacterial InfectionsBehaviorBiochemicalBiochemistryBiological ChemistryCell BodyCell Communication and SignalingCell DensityCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCellsChemicalsChemistryChronic DiseaseChronic IllnessClinicalCommunicationDevelopmentEnvironmentFoundationsGeneticGoalsGram-Negative BacteriaHealthHumanIndividualInfectionInterceptIntracellular Communication and SignalingLaboratoriesLeadLeadershipLife StyleLifestyleLigandsMaintenanceMethodsMicrobiologyModern ManMolecularNational Institutes of HealthOrganismOutcomePathway interactionsPb elementPopulationPositionPositioning AttributeProcessR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinReceptor SignalingResearchResearch GrantsResearch Project GrantsResearch ProjectsRoleShapesSightSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSystemTestingUnited States National Institutes of HealthVirulenceVisionWorkacute disease/disorderacute disorderanti-microbialantimicrobialattenuateattenuatesbacteria infectionbacterial diseasebiological signal transductionchronic disordercommunity microbesdevelopmentalheavy metal Pbheavy metal leadinsightintercellular communicationliving systemmicrobe communitymicrobial communitymicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramicroorganism communitymultispecies consortianew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpathwaypolymicrobial communityquorum sensingreceptorsmall moleculesocial roletoolvisual function
Description preview
PROJECT SUMMARY/ABSTRACT
This MIRA proposal focuses on the remarkable ability of bacteria to switch from a single cell to a group lifestyle
using simple chemical signals, a process called “quorum sensing” (QS). QS has a major impact on human
health, with some of the most common pathogens utilizing this signaling mechanism to regulate…
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