grant
Chemical strategies to investigate biochemical crosstalk in human chromatin
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026Antioncogene Protein p53AssayBasal Transcription FactorBasal transcription factor genesBase PairingBasic Mechanisms of SUMOylationBioassayBiochemicalBiologicalBiological AssayBiophysicsCell BodyCellsCellular Tumor Antigen P53ChemicalsChromatinChromatin StructureComplexDiseaseDisorderGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGoalsHeterogeneityHistone H2BHistone H4HistonesHumanMethylationModern ManModificationMolecularNucleoproteinsOncoprotein p53P53Phosphoprotein P53Phosphoprotein pp53PlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein FamilyProtein ModificationProtein TP53ProteinsR-Series Research ProjectsR01 MechanismR01 ProgramRegulationResearch GrantsResearch Project GrantsResearch ProjectsRoleSUMOylationSiteSumoylation PathwayTP53TP53 geneTRP53TechniquesTranscription Factor Proto-OncogeneTranscription factor genesTumor Protein p53Tumor Protein p53 Genebiologicbiophysical foundationbiophysical principlesbiophysical sciencescell engineeringcellular engineeringgene functiongenetic informationhistone modificationhuman diseasenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetp53 Antigenp53 Genesp53 Tumor Suppressorprotein p53social rolesynthetic proteintherapeutic targettooltranscription factor
Description preview
PROJECT SUMMARY
Chromatin is a massive nucleoprotein complex that packages about three billion
base pairs of genetic information in nucleated cells. Histones and transcription factors
(TFs) are two important families of proteins associated with chromatin that play key
roles in organizing, protecting and activating our genes. A conserved feature…
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