grant
Chemical glycobiology tool development: Proximity-based modalities
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Jan 1999Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeASGP-RAffectAntibodiesAntibody-drug conjugatesAntigensAsialoglycoprotein ReceptorAsialoorosomucoid ReceptorAsialoorosomucoid-Binding ProteinAutoimmune DiseasesB blood cellsB cellB cellsB-Cell Antigen CD22B-CellsB-LymphocytesB-cellB3 antigenBasic ResearchBasic ScienceBindingBiologicalCD22CD22 antigenCD22 geneCIMPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer TreatmentCancersCell Surface ReceptorsCell membraneCell surfaceChemicalsChimeraChimera organismComplexCytoplasmic MembraneDevelopmentDevelopment and ResearchE3 LigaseE3 Ubiquitin LigaseEngineeringEnzyme GeneEnzymesExtracellular ProteinFundingGluesGlycansGlycobiologyGlycoproteinsGoalsGrantIGF Type 2 ReceptorIGF-2 ReceptorIGF-II ReceptorIGF2RIGF2R geneImmune mediated therapyImmunologically Directed TherapyImmunotherapyInsulin-Like Growth Factor 2 ReceptorInsulin-Like Growth Factor II ReceptorInsulin-Like Growth Factor Type 2 ReceptorLigandsLinkLiverLysosomesMPRIMacropainMacrophageMacrophage ActivationMacroxyproteinaseMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMannose 6-Phosphate Receptor, Cation-IndependentMannose-6-Phosphate ReceptorMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolic Protein DegradationModalityMolecularMolecular InteractionMulticatalytic ProteinaseMφOutcomePeripheralPlasma MembranePolysaccharidesProsomeProtacProteasomeProteasome Endopeptidase ComplexProtein SecretionProtein TurnoverProteinsProteolysis targeting chimericProteosomeR & DR&DReceptor ProteinRegulatory Protein DegradationResearchSIGLEC2Sialic Acid-Binding Immunoglobulin-Like Lectin 2StructureSurface ProteinsTechnologyTumor AntigensTumor-Associated AntigenTumor-associated macrophagesTumor-infiltrating immune cellsUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3VHHVHH antibodyWorkanti-cancer therapyautoimmune conditionautoimmune disorderautoimmune toxicityautoimmunity diseasebiologiccamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincancer antigenscancer therapycancer-directed therapycell typecheck point receptorscheckpoint receptorschimeraschimeric antibodyclinical candidateclustered regularly interspaced short palindromic repeats screendesigndesign and constructdesign and constructiondesigningdevelopmentaldrug developmentextracellularhepatic body systemhepatic organ systemhuman diseaseimmune cell infiltration of tumorsimmune cells infiltrating the tumorimmune cells that infiltrate the tumorimmune check pointimmune checkpointimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmunecheckpointimmuno therapyimmunogeninfiltration of tumors by immune cellsintratumoral immune cellintratumoral immune infiltratemalignancymulticatalytic endopeptidase complexnanobodiesnanobodynative protein drugneoplasm/cancernovelpharmaceutical proteinplasmalemmaprotein degradationprotein drug agentprotein-based drugproteolysis targeting chimaeraproteolysis targeting chimerareceptorreceptor bindingreceptor boundresearch and developmentsdAbsingle domain antibodiestechnology platformtechnology systemtherapeutic proteintooltool developmenttraffickingtumor immune celltumor immune infiltratetumor infiltration of immune cellstumor-specific antigenubiquitin-protein ligasevariable heavy chain antibody
Description preview
PROJECT SUMMARY
This is a renewal application of R01GM058867 which has supported our foundational efforts in chemical glycobiology tool development since 1999. Our current goal is to leverage glycochemistry and glycobiology in the development of proximity-based technologies for use in basic research and drug development.
Molecules designed to…
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