grant
Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 14 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025ASCVDAbscissionAddressAffinityAnimalsApo E ReceptorApoE ReceptorApolipoprotein E ReceptorAtherosclerosisAtherosclerotic Cardiovascular DiseaseAvesAvianBindingBiochemicalBiochemistryBiologicalBiological ChemistryBiological TerrorismBiologyBioterrorBioterrorismBirdsBody TissuesBrainBrain Nervous SystemBrazilBunyaviralesBunyavirusCHIKV feverCancersCategory A pathogenCategory A priority pathogenCell BodyCell LineCellLineCellsChikungunya feverChildhoodCollaborationsComplementComplement ProteinsComplexCoupledCulicidaeDataDegenerative Neurologic DisordersDengueDengue FeverDengue diseaseDiseaseDisease OutbreaksDisease OutcomeDisorderDistantDrug TherapyDrug or chemical Tissue DistributionEmerging Communicable DiseasesEmerging Infectious DiseasesEncephalonEndocytosisEpidemicExcisionExtirpationFamilyFamily memberFeverFrequenciesGeneral TaxonomyGenomicsGlycoproteinsHealthHost FactorHost Factor ProteinHumanHuman BiologyImmunologyIn VitroInfectionInsectaInsectsInsects InvertebratesIntegration Host FactorsInvestigatorsKidneyKidney Urinary SystemKnowledgeLDLLDL LipoproteinsLDL ReceptorsLDL-Receptor Related Protein 1LDLR geneLa Crosse encephalitis virusLa Crosse virusLaCrosse encephalitis virusLaCrosse virusLigandsLipoprotein LDL ReceptorsLipoprotein ReceptorLiverLow Density Lipoprotein ReceptorLow Density Lipoprotein Receptor-Related ProteinLow-Density LipoproteinsLow-Density-Lipoprotein Receptor-Related Protein-1Malignant NeoplasmsMalignant TumorMammaliaMammalsMiceMice MammalsModern ManMolecularMolecular InteractionMosquitoesMurineMusNIAIDNational Institute of Allergy and Infectious DiseaseNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNorth AmericaOropoucheOropouche virusOrthobunyavirusOutbreaksPathogenesisPeripheralPharmacological TreatmentPharmacotherapyPlayProductivityProteinsProteomicsPyrexiaReceptor CellReceptor ProteinRemovalReportingReptilesReptiliaResearch PersonnelResearchersRift Valley fever virusRoleRouteSequence HomologySouth AmericaSpleenSpleen Reticuloendothelial SystemStrains Cell LinesStructureSurgical RemovalTaxonomyTestingTherapeuticTissue DistributionTissuesTropismUnited StatesVaccinesValidationViralViral DiseasesViral EncephalitisViral Infectious EncephalomyelitisViral PathogenesisVirusVirus DiseasesVirus ReplicationWorkalpha-2-Macroglobulin Receptoralpha2-Macroglobulin Signaling Receptorarboviral diseasearbovirus diseasearthropod transmissionarthropod transmittedarthropod-bornearthropod-borne diseasearthropodbornearthropodborne diseaseatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebeta-Lipoproteinsbiologicbreakbone feverchikungunyaclimate changeclimatic changescomplementationcultured cell linedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdrug interventiondrug treatmentepidemic planningepidemic preparednessfebrilefebrisglobal climate changeglobal healthhepatic body systemhepatic organ systemhuman diseasehuman pathogenin vivoinnovateinnovationinnovativemalignancymembermouse modelmurine modelneoplasm/cancerneurodegenerative illnessnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpandemic concernpandemic potentialpandemic riskpandemic threatpathogenpediatricpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingprogramsreceptorrenalresectionsocial rolestructural biologytherapeutic agent developmenttherapeutic developmentvalidation studiesvalidationsvector tickviral infectionviral multiplicationviral replicationviral transmissionvirologyvirus infectionvirus multiplicationvirus pathogenesisvirus transmissionvirus tropismvirus-induced disease
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Project Summary/Abstract
Bunyaviruses (Order: Bunyavirales) are a growing and diverse family of animal and human pathogens with
pandemic potential. With over 300 members and an expanding distribution of mosquito and tick vectors due to
climate change, these viruses are responsible for increasing outbreaks of human disease and present a
significant…
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