grant
Characterizing the Role of Autophagy in Type 1 Diabetes Development
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 15 May 2025Deadline 14 May 2029
NIHUS FederalResearch GrantFY20250-11 years oldAchievementAchievement AttainmentAdvisory CommitteesAffectAgeAntigensAutoimmuneAutoimmune ResponsesAutophagocytosisAwardB9 endocrine pancreasBeta CellBiochemicalBrittle Diabetes MellitusCardiac infarctionCathepsinsCell BodyCell LineCell SurvivalCell ViabilityCellLineCellsCellular StressCellular Stress ResponseCessation of lifeChildChild YouthChildhoodChildren (0-21)ChronicClinicalClinical EndocrinologyCollaborationsCommunicationDNA Molecular BiologyDataDeathDegradation PathwayDegradative PathwayDevelopmentDiabetes MellitusDiagnosisDiseaseDisorderDysfunctionER stressEndocrine PancreasEndoplasmic ReticulumEnvironmentEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzymesErgastoplasmEsteroproteasesExocytosisFellowshipFunctional disorderFutureGeneticGoalsHealthHeat shock proteinsHumanHumulin RHybridsIDDMImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmune TargetingImmune destructionImmune infiltratesImmune mediated destructionImmune responseImmunesImpairmentInbred NOD MiceIncidenceIndianaInflammationInflammatoryInsulinInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusInvestigationInvestigatorsIslands of LangerhansIslet CellIslets of LangerhansJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLaboratoriesLinkLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesLysosomesMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMedicalMetabolic DiseasesMetabolic DisorderMetabolic Protein DegradationMiceMice MammalsModelingModern ManMolecular BiologyMolecular Biology TechniquesMurineMusMyocardial InfarctMyocardial InfarctionNOD MouseNesidioblastsNon-Obese Diabetic MiceNonobese Diabetic MouseNovolin ROralOrganellesPancreasPancreaticPancreatic IsletsPancreatic beta CellPancreatic β-CellPars endocrina pancreatisPathogenesisPathogenicityPathway interactionsPeptidasesPeptide FragmentsPeptide HydrolasesPeptidesPersonsPhysiciansPhysiopathologyPlayPredisposition genePreventionProcessProductionProinsulinProtease GeneProteasesProtein TurnoverProteinasesProteinsProteolytic EnzymesProteomicsRegular InsulinRegulatory Protein DegradationResearchResearch PersonnelResearch TrainingResearchersRoleScientistSourceStrains Cell LinesStressStructureStructure of beta Cell of isletSudden-Onset Diabetes MellitusSurfaceSusceptibility GeneT1 DMT1 diabetesT1DT1DMTask ForcesTechnical ExpertiseTestingTherapeuticThesaurismosisTrainingTraining ProgramsType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited StatesUniversitiesUpregulationVesicleWritingadvisory teamagesautoimmune beta cell destructionautoimmune islet destructionautophagyautoreactive T cellbafilomycin A1beta cell autoimmunitybiological adaptation to stresscardiac infarctcardiovascular disease riskcardiovascular disorder riskcareercell stressclinical careclinical developmentclinical trainingcoronary attackcoronary infarctcoronary infarctioncultured cell linedesigndesigningdevelopmentaldiabetesdiabetes pathogenesisdiabetogenicendoplasmic reticulum stressenvironmental riskexperimentexperimental researchexperimental studyexperimentsheart attackheart infarctheart infarctionhost responseimmune cell infiltrateimmune system responseimmunogenimmunogenicimmunogenicityimmunoresponsein vitro Modelin vivoinhibition of autophagyinhibitorinsulin dependent diabetesinsulin dependent diabetes mellitus onsetinsulin dependent type 1insulin granuleisletislet autoimmunityislet cell autoimmunityjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidslearning activitylearning methodlearning strategieslearning strategylife spanlifespanlymph glandlymph nodeslymphnodesmedical collegemedical schoolsmetabolism disordermouse modelmurine modelneo-antigenneo-epitopesneoantigensneoepitopesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-obese diabetic (NOD) micenonobese diabetic (NOD) micenovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpancreas beta cellpancreas β cellpancreatic b-cellpathophysiologypathwaypediatricpharmacologicpredisposing genepreventpreventingprotein degradationreaction; crisisrecruitresponseschool of medicineself-reactive T cellskillssocial rolestress proteinstress responsestress; reactionsusceptibility allelesusceptibility locussusceptibility varianttechnical skillstherapeutic targettranscriptomicstype 1 diabetes onsettype I diabetestype one diabetesyoungsterβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY/ABSTRACT
Type 1 Diabetes (T1D) develops following autoimmune-mediated destruction of pancreatic β-cells and is caused
by a combination of genetic and environmental factors. However, the mechanisms that lead to autoimmune
targeting of the β-cell remain incompletely understood. One potential contributing factor is defective β-cell…
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