grant
Characterizing the pathophysiological role of the pallido-thalamocortical motor pathway in Parkinson's disease
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AccelerationAlgorithmsAxonBasal GangliaBasal NucleiBiological MarkersBiophysicsBradykinesiaBrainBrain Nervous SystemCharacteristicsClinicalComputer ModelsComputerized ModelsDataDeep Brain StimulationDevelopmentDorsalElectrocorticogramEncephalonExhibitsFollow-Up StudiesFollowup StudiesFrequenciesGlobus PallidusGoalsHigh Frequency OscillationImageImplantIndependent LivingLateralLeadLocationMeasuresMicroelectrodesMiniaturized ElectrodesModelingMotorMotor CortexMotor PathwaysMovementNeural PathwaysOperating RoomsOperative ProceduresOperative Surgical ProceduresOutcomeParalysis AgitansParkinsonParkinson DiseasePathway interactionsPatientsPb elementPhysiologicPhysiologicalPlayPositionPositioning AttributePostoperativePostoperative PeriodPreparationPrimary ParkinsonismReportingResolutionRestRoleSeveritiesSiteSpatial DistributionSurgicalSurgical InterventionsSurgical ProcedureTechnologyThalamic structureThalamusTimeawakebio-markersbiologic markerbiomarkerbiomarker identificationbiophysical foundationbiophysical modelbiophysical principlesbiophysical sciencesbody movementcomputational modelingcomputational modelscomputer based modelscomputerized modelingcustomized therapycustomized treatmentdegree pathdegree pathwaydevelopmentaldisabilityeducation patheducation pathwayeffective therapyeffective treatmentelectrocorticographyheavy metal Pbheavy metal leadhigh resolution imagingidentification of biomarkersidentification of new biomarkersimagingimprovedimproved motor functionindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativemarker identificationmeetingmeetingsmotor function improvementneuralneurophysiologicalneurophysiologynovelpallidumparticipant enrollmentpathwaypatient enrollmentpatient specific therapiespatient specific treatmentpotential biological markerpotential biomarkerpreparationsresolutionssocial rolesurgerytailored medical treatmenttailored therapytailored treatmentthalamictoolunique treatment
Description preview
ABSTRACT
Although studied for decades, the physiological changes in the basal ganglia thalamocortical (BGTC) circuit that
underlie the development of motor signs of Parkinson’s disease (PD) remain under debate. Excessive
synchronization and coherence in neural activity has been demonstrated within the internal segment of the
globus pallidus (GPi)…
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