grant
Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis
Organization SLOAN-KETTERING INST CAN RESEARCHLocation NEW YORK, UNITED STATESPosted 23 Feb 2018Deadline 31 May 2028
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAccelerationActive OxygenAffectAmino Acid SequenceAmino AcidsAreaAutoimmune DiseasesAutoregulationBiologyC-terminalCancer CauseCancer EtiologyCancersCell BodyCell Communication and SignalingCell ComponentsCell DeathCell SignalingCell StructureCellsCellular Metabolic ProcessCellular StructuresCommunicable DiseasesComplexCysteineDataDegenerative Neurologic DisordersDipeptidesDipeptidyl AminopeptidasesDipeptidyl PeptidasesDipeptidylpeptide HydrolasesDiseaseDisorderFoundationsFutureHalf-CystineHealthHomeostasisHumanImmune responseImmunityInfectious DiseasesInfectious DisorderInflammasomeInflammatoryInnate Immune SystemInnate ImmunityIntracellular Communication and SignalingKnowledgeL-CysteineL-ProlineL-SerineLaboratoriesLengthLigand BindingLinkLyticMacromolecular Protein ComplexesMacropainMacroxyproteinaseMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetabolicMetabolic DiseasesMetabolic DisorderMetabolic Protein DegradationMetabolic dysfunctionMitochondriaModern ManMolecularMonitorMulticatalytic ProteinaseMultiprotein ComplexesN-terminalNH2-terminalNative ImmunityNatural ImmunityNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-Specific ImmunityNonspecific ImmunityOxidation-ReductionOxygen RadicalsPaperPattern recognition receptorPeptidesPhysiological HomeostasisPlayPrimary Protein StructurePrintingPro-OxidantsProcessProlineProsomeProteasomeProteasome Endopeptidase ComplexProtein RegionProtein TurnoverProteinsProteomicsProteosomePublic HealthR-Series Research ProjectsR01 MechanismR01 ProgramReactive Oxygen SpeciesRedoxRegulatory Protein DegradationReportingRepressionResearchResearch GrantsResearch Project GrantsResearch ProjectsSerineSignal TransductionSignal Transduction SystemsSignalingStressT-CellsT-LymphocyteTherapeuticThesaurismosisWorkaminoacidautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductioncell metabolismcellular metabaolismdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisulfide bondhost responsehuman diseaseimmune system responseimmunoresponseinhibitormalignancymetabolism disordermitochondrialmulticatalytic endopeptidase complexnecrocytosisneoplasm/cancerneurodegenerative illnessoxidation reduction reactionpathogenpeptide mimeticpeptide mimicpeptidomimeticsprotein degradationprotein sequencereceptor bindingreceptor boundsmall moleculethymus derived lymphocyte
Description preview
PROJECT SUMMARY
Several human pattern-recognition receptors detect intracellular danger-associated signals, oligomerize into
multiprotein complexes called inflammasomes, and trigger a lytic form of cell death called pyroptosis.
Inflammasomes are involved in mounting immune responses to pathogens and in maintaining organismal
homeostasis, but their…
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