grant

Characterizing the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens

Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 10 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AddressAfricaAutoimmune DiseasesBiologyCell BodyCellsChronicCommunicable DiseasesComplexDiseaseDisorderEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionGene ExpressionGene TranscriptionGene variantGenesGeneticGenetic DifferentiationGenetic DivergenceGenetic DiversityGenetic DriftGenetic TranscriptionGenetic VariationGenomicsHost DefenseHumanHuman GenomeHuman Migration / DistributionImmuneImmune responseImmune systemImmunesImmunityIndividual DifferencesInfectionInfectious AgentInfectious DiseasesInfectious DisorderInflammatoryModern ManModernizationMolecularNatural SelectionsPathogenicityPhenotypePlayPopulationPredispositionRNA ExpressionResearchRoleShapesStimulusSusceptibilityTranscriptionVariantVariationallelic variantautoimmune conditionautoimmune disorderautoimmunity diseaseepigeneticallygenetic variantgenomic varianthost responsehuman migrationhuman whole genomeimmune system responseimmunoresponseinfancyinfantileinfectious organismpathogenpressureprogramsresponsesocial roletrait
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Project Summary
Pathogens are one of the strongest selective pressures on the human genome. As modern humans migrated

out of Africa, they encountered markedly different pathogenic environments, likely resulting in population-specific

selection of immune phenotypes. Consistent with this hypothesis, some of the most compelling evidence for

local…

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Characterizing the genetic and evolutionary determinants of population variation in transcriptional responses to pathoge | Dev Procure