grant
Characterizing the effect of transcription-replication conflicts on transcription and co-transcriptional processes
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 15 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AccidentsAffectAgingAlternate SplicingAlternative RNA SplicingAlternative SplicingAutoregulationCancersCell BodyCellsComplexDNA DamageDNA InjuryDNA ReplicationDNA SynthesisDNA biosynthesisDNA-Dependent RNA Polymerase IIDedicationsDevelopmentDiseaseDisorderFaceFutureGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenetic TranscriptionGenomeGenome InstabilityGenomic DNAGenomic InstabilityGoalsHomeostasisHumanIsoformsKineticsMalignant NeoplasmsMalignant TumorModern ManOncogene ActivationOncogenesisPathologicPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisPoly APoly(rA)PolyadenylationProcessProductionProliferatingProtein IsoformsRNA ExpressionRNA PolyadenylationRNA Polymerase BRNA Polymerase IIRegulationReplication OriginReplication ProcessReplication-Associated ProcessRoleSpeedTimeTranscriptTranscriptionTranscription Initiation SiteTranscription ProcessTranscription Start SiteVariantVariationWorkcell typecircular RNAclosed circular RNAconflict resolutiondevelopmentalfacesfacialfitnessgDNAmalignancyneoplasm/cancerori Regionpathwaypolyadenylateprogramssmall moleculesocial rolespatial and temporalspatial temporalspatiotemporaltranscription terminationtumorigenesis
Description preview
PROJECT SUMMARY
Coordination between the replication and transcription process is one of the major challenges that cells face during
proliferation. As both replication and transcription machinery use the same genomic DNA as a template, to avoid conflicts,
spatial-temporal separation between these two processes is necessary. Cells have evolved…
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