grant
Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AddressAffectAfter CareAfter-TreatmentAftercareAntigensAssayB blood cellsB cellB cellsB lymphomaB-Cell ActivationB-Cell LymphomasB-CellsB-LymphocytesB-cellBioassayBiological AssayCD154CD40LCD40LGCancerousCell BodyCell Communication and SignalingCell ReprogrammingCell SignalingCell SurvivalCell ViabilityCellsChromatinDLBCLDNA mutationDependenceDevelopmentDiagnosticDiffuse Large B-Cell LymphomaDiseaseDisease ProgressionDisorderDown-RegulationEndowmentEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExpression SignatureGene Expression ProfileGene TranscriptionGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGerminal CenterGerminoblastic SarcomaGerminoblastomaGoalsHematopoietic Cell TumorHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsHistone H1ImageImmuno-ChemotherapyImmunobiologyImmunochemotherapyImmunophysiologyIncidenceIntracellular Communication and SignalingLymphomaLymphoma cellLymphomagenesisMaintenanceMalignant Hematopoietic NeoplasmMalignant LymphomaMature B-CellMature B-LymphocyteMature LymphocyteMolecularMutationNatureOncogenesisPatientsPopulationProgenitor CellsPropertyPublishingRNA ExpressionReactionRegimenRelapseResearchResidualResidual stateResistanceReticulolymphosarcomaRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSolid NeoplasmSolid TumorStem Cell likeStructure of germinal center of lymph nodeT-CellsT-LymphocyteTNFSF5TNFSF5 geneTRAP GeneTechnologyTestingTherapeuticTranscriptionWorkactivated B cellsbiological signal transductionblood cancercancer of bloodcancer of the bloodcellular reprogrammingchemo-immuno therapychemoimmunotherapychromatin remodelingderepressiondevelopmentalepigeneticallyexperiencegain of functiongene expression patterngene expression signaturegenome mutationiPSiPSCiPSC technologyiPSCsimagingimmunogenin vivoinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell technologyinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativelarge cell Diffuse non-Hodgkin's lymphomaleukemialoss of functionmouse modelmurine modelnovelpathogenpost treatmentpreventpreventingprogenitorprogenitor capacityprogenitor cell geneprogenitor cell likeprogenitor geneprogenitor-likeprogenitor-like cellprogramsrelapse patientsrelapse riskresistantresponseself-renewself-renewalsingle cell technologysocial rolespatial multiomicsspatial omicsspatial tri-omicsstem cell characteristicsstem cell genesstem cellsstem-likestem-like cellstemnesssynergismtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetranscriptional profiletranscriptional reprogrammingtranscriptional signaturetumortumorigenesistumorigenic
Description preview
One third of B-cell lymphoma patients relapse and remain incurable despite effective targeted
therapies. Although, the serially relapsing nature of these tumors support the presence of stem-
like lymphoma repopulating cells, this notion remains controversial and underexplored.
Resistance to this concept arise from the fact that -in contrast to…
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