grant
Characterizing NLRP11 Activation by Mycobacteria to Enhance Innate Immune Responses
Organization UNIV OF MARYLAND, COLLEGE PARKLocation COLLEGE PARK, UNITED STATESPosted 2 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026Acid FastAcid Fast BacillaeAcid Fast Bacillae Staining MethodBacteriaBacterial InfectionsBindingCancer InductionCaspaseCaspase GeneCell BodyCell WallCell-Death ProteaseCellsClinicalCollectionCommunitiesComprehensionCosmidsCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCytosolDNADNA SequenceDeoxyribonucleic AcidDetectionEngineeringFutureGene DeletionGenesGeneticGenomic DNAGenus MycobacteriumGram-Negative BacteriaHumanICE-like proteaseImmune responseInfectionInflammasomeInnate Immune ResponseKnock-outKnockoutKnowledgeLibrariesLigandsLipidsLipopolysaccharidesM bovisM kansasiiM smegmatisM tbM tuberculosisM tuberculosis H37RvM. bovisM. kansasiiM. smegmatisM. tbM. tuberculosisM. tuberculosis H37RvM. tuberculosis complexM.tb complexMTB vaccineMacrophageMalignant CellModern ManMolecularMolecular InteractionMtb complexMycobacteriumMycobacterium bovisMycobacterium kansasiiMycobacterium smegmatisMycobacterium tuberculosisMycobacterium tuberculosis H37RvMycobacterium tuberculosis complexMycobacterium tuberculosis var. bovisMφPathway interactionsPhenotypePrimatesPrimates MammalsProteinsResearchResearch ResourcesResourcesStructureSubcellular FractionsTB vaccineTransfectionTuberculosis VaccinesVaccine for TBVaccine for TuberculosisVaccinesadaptive immune responseanti-TB vaccinebacteria infectionbacterial diseasecancer cellcarcinogenesiscystein proteasecystein proteinasecysteine endopeptidasedepositorydiscover genesgDNAgain of functiongene deletion mutationgene discoveryhost responsehuman pathogenimmune system responseimmunogenicityimmunoresponseimprovedinsightmtbmutantmycobacterialnon-tuberculosis mycobacterianon-tuberculosis mycobacterialnon-tuberculous mycobacterianon-tuberculous mycobacterialnontuberculosis mycobacterialnontuberculous mycobacterianontuberculous mycobacterialnovelopportunistic pathogenoverexpressoverexpressionpathogenpathwayrepositoryscreeningscreeningstumorvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine candidates against tuberculosis
Description preview
The NLRP11 protein is only expressed in primates and participates in the activation of the
canonical NLRP3 and non-canonical caspase-4 inflammasome activation after infection with
gram-negative bacteria. We found that the atypical gram-positive pathogen Mycobacterium
tuberculosis (Mtb) and the opportunistic pathogen M. kansasii both activate the…
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