grant
Characterizing autoreactive B cells and their roles in the pathogenesis of SLE using immune organoids
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026(TNF)-αACPAAGP7AffectAffinityAntibodiesAntigensAssayAutoantibodiesAutoantigensAutoimmuneAutoimmune DiseasesAutoimmune ResponsesAutoimmune StatusAutoimmunityAutologous AntigensAutomobile DrivingB blood cellsB cellB cell receptorB cellsB-Cell ActivationB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellB-cell receptor repertoire sequencingB-cell receptor sequencingBCR repertoire sequencingBCR seqBCR sequencingBCRseqBacteriaBindingBioassayBiological AssayBlood monocyteCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCachectinCas nuclease technologyCell BodyCell Communication and SignalingCell SignalingCellsCharacteristicsClonal ExpansionClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-cultureCocultivationCocultureCoculture TechniquesComplexDNA mutationDevelopmentDideoxy Chain Termination DNA SequencingDysfunctionFrequenciesFunctional disorderGene AlterationGene MutationGene TranscriptionGene variantGenerationsGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGerminal CenterHistonesHumanHyperactivityIFN-GammaIFN-gIFN-γIFNGIFNγIg Somatic HypermutationImmuneImmune Cell ActivationImmune InterferonImmunesImmunoglobulin Somatic HypermutationIndividualInfectionInflammationInflammatoryInflammatory ResponseInterferon GammaInterferon Type IIInterventionIntracellular Communication and SignalingInvestigationLinkLuciferase ImmunologicLuciferasesLupusLupus Erythematosus DisseminatusMacrophageMacrophage-Derived TNFMarrow monocyteMediatingMethodologyModelingModern ManMolecular InteractionMonocyte-Derived TNFMureinMutationMφOrganoidsPBMCPR3PRTN3PRTN3 genePathogenesisPathogenicityPathway interactionsPatientsPeptidoglycanPeripheral Blood Mononuclear CellPersonsPhenotypePhysiopathologyProductionRNA ExpressionRNA SeqRNA sequencingRNAseqRecombinantsRoleSLESanger SequencingSelf-AntigensSignal TransductionSignal Transduction SystemsSignalingSortingSpleenSpleen Reticuloendothelial SystemStructure of germinal center of lymph nodeSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTLR7TLR7 geneTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTechnologyTestingToll-Like Receptor 7TranscriptionTumor Necrosis FactorTumor Necrosis Factor-alphaUnited StatesUpregulationVariantVariationactivated B cellsallelic variantautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive B cellautoreactive antibodybiological signal transductionclinical relevanceclinically relevantcytokinedevelopmentaldisease subgroupsdisease subtypedisorder subtypedisseminated lupus erythematosusdrivinggene defectgene editing platformgene editing systemgene editing technologygene editing toolsgene-editing toolkitgenetic variantgenome mutationgenomic variantimmune activationimmunogeninsightlFN-Gammamonocytemutantmutant allelenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpathogenic autoantibodiespathophysiologypathwaypersonalization of treatmentpersonalized health interventionpersonalized interventionpersonalized medicinepersonalized therapypersonalized treatmentprecision interventionsresponsescRNA sequencingscRNA-seqself reactive B cellself reactive antibodysingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesomatic hypermutationsuccesssystemic autoimmune diseasesystemic autoimmune disordersystemic lupus erythematosistranscriptome sequencingtranscriptomic sequencingtranscriptomics
Description preview
Project Summary
Systemic lupus erythematosus (SLE) is a complex autoimmune disease driven by the breakdown of B
cell tolerance and the production of autoreactive antibodies. We recently identified the presence of
autoreactive B cells in spleens from healthy individuals and observed a 20-fold increase in spleens
derived from SLE patients. This…
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