grant
Characterizing Alzheimer's disease molecular and anatomical imaging markers and their relationships with cognition and genetics using machine learning
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAPOEAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAmentiaAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinApo-EApoE proteinApolipoprotein EAβBehaviorBehavioralBrainBrain Nervous SystemBrain regionClinicalClinical EvaluationClinical MarkersClinical TestingCognitionCognitiveComplexComputer AssistedConnectionist ModelsDataData SetDegenerative Neurologic DisordersDementiaDiagnosisDiagnosticDisease OutcomeDysfunctionEncephalonExhibitsExpression SignatureFunctional disorderFutureGene Expression ProfileGeneticGenetic MarkersGoalsHeterogeneityImageInvestigatorsKnowledgeMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMT-bound tauMachine LearningMagnetic Resonance ImagingMeasurementMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental disordersMental health disordersMethodsMultimodal ImagingNMR ImagingNMR TomographyNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural Network ModelsNeural Network SimulationNeural degenerative DisordersNeuritic PlaquesNeurobiologyNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPETSCANPETTParticipantPatientsPatternPerceptronsPersonsPhenotypePhysiopathologyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrecision therapeuticsPreparationPrimary Senile Degenerative DementiaPsychiatric DiseasePsychiatric DisorderPsychosesRad.-PETResearchResearch PersonnelResearchersScienceSenile PlaquesSubgroupSumSymptomsTechniquesTestingTherapeuticTranslatingUnited StatesUniversitiesVariantVariationWashingtonZeugmatographya beta peptideabetaamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinanatomic imaginganatomical imagingaβ plaquesbehavior phenotypebehavioral phenotypingbeta amyloid fibrilbrain basedclinical biomarkersclinical phenotypeclinical testclinically useful biomarkerscognitive performancecomputer aidedcored plaquedeep learning based neural networkdeep learning neural networkdeep neural netdeep neural networkdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdiffuse plaquedisease heterogeneitygene biomarkergene expression biomarkergene expression patterngene expression signaturegene markergene signature biomarkergenetic biomarkerimage-based methodimagingimaging biomarkerimaging markerimaging methodimaging modalityimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedimproved outcomein vivoinnovateinnovationinnovativemachine based learningmachine learning based methodmachine learning based modelmachine learning based prediction modelmachine learning based predictive modelmachine learning methodmachine learning methodologiesmachine learning modelmachine learning predictionmachine learning prediction modelmagnetic resonance imaging biomarkermagnetic resonance imaging markermental illnessmental statemental statusmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmolecular imagingmolecule imagingmulti-modal imagingmulti-modality imagingmultimodality imagingneural degenerationneural imagingneuro-imagingneurobiologicalneurobiological mechanismneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologicneuropathologicalneuropathologyneuropsychiatric diseaseneuropsychiatric disordernovelpathophysiologypatient living with Alzheimer's diseasepatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepolygenetic risk scorespolygenic risk scorepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalprecision medicineprecision therapiesprecision treatmentprecision-based medicinepreclinicalpreparationsprimary degenerative dementiaprognosticpsychiatric illnesspsychological disorderpublic health relevanceresearch clinical testingresponse to therapyresponse to treatmentsenile dementia of the Alzheimer typesoluble amyloid precursor proteinsuccesssupervised learningsupervised machine learningsupport vector machinetangletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau Proteinstau factortherapeutic biomarkertherapeutic markertherapeutic responsetherapy responsetranscriptional profiletranscriptional signaturetreatment responsetreatment responsivenessτ Proteins
Description preview
Project Summary
Amyloid-beta and tau are hallmarks of mild cognitive impairment (MCI)/Alzheimer’s disease (AD). The
relationships of in-vivo amyloid-beta, tau, and neurodegeneration with cognitive, clinical, and genetic markers
are not well understood. Patients with AD pathology exhibit heterogeneity in their clinical symptoms and illness
course.…
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