grant
Characterization of PHF7 function in mediating cardiac reprogramming
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldATACATAC sequencingATAC-seqATACseqAcuteAddressAdultAdult HumanAdvisory CommitteesAssayAssay for Transposase-Accessible Chromatin using sequencingAwardBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBioassayBiological AssayBiologyCalciumCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiac infarctionCardiocyteCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell ReprogrammingCellsChIP SequencingChIP-seqChIPseqChromatinChromiumChronicCombining SiteCr elementDNA Molecular BiologyDataDevelopmentEnhancersEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFellowshipFibroblastsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGATA binding protein 4GATA4GATA4 geneGATA4 transcription factorGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGoalsGrantHealth ExpendituresHeartHeart DiseasesHeart Muscle CellsHeart VascularHeart failureHeart myocyteHistologicHistologicallyHistonesHumanInjectionsInjuryInstitutionInternal MedicineInvestigatorsIschemic HeartIschemic Heart DiseaseIschemic myocardiumLPTNLaboratoriesMating Type Switching/Sucrose Nonfermenting ProteinMediatingMedicalMentorsMentorshipMiceMice MammalsModalityModern ManModificationMolecular BiologyMolecular InteractionMorbidityMorbidity - disease rateMurineMusMuscleMuscle CellsMuscle TissueMyocardial InfarctMyocardial InfarctionMyocardial IschemiaMyocardiumMyocytesNatural regenerationPatientsPhysiciansPositionPositioning AttributePostdocPostdoctoral FellowProductivityRNA ExpressionRNA SeqRNA sequencingRNAseqReactive SiteReaderRegenerationResearchResearch AssociateResearch PersonnelResearch ResourcesResearchersResidenciesResourcesRoleSCM-1SCM-1aSCM1SCYC1SWI/SNF ComplexSWI/SNF Family ComplexScientistSupporting CellTask ForcesTechnologyTestingTrainingTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTreatment FactorUniversitiesWorkXCL1XCL1 geneadulthoodadvisory teamanalyze gene expressionassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcardiac failurecardiac functioncardiac infarctcardiac ischemiacardiac musclecardiac regenerationcardiomyocytecareercareer developmentcellular reprogrammingchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcirculatory systemclinical applicabilityclinical applicationclinical significanceclinical translationclinically significantclinically translatablecofactorcoronary attackcoronary infarctcoronary infarctioncoronary ischemiadetermine efficacydevelopmentalefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationepigeneticallyepigenomeepigenomicsevaluate efficacyexamine efficacyflow cytophotometryfunction of the heartgene expression analysisgene expression assaygenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehealth care expenditureheart attackheart disorderheart functionheart infarctheart infarctionheart ischemiaheart muscleheart regenerationimmunocytochemistryimprovedin vivoinjuriesinjury responsemedical expendituremortalitymultiomicsmultiple omicsmuscularmyocardial ischemia/hypoxiamyocardium ischemianew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpanomicsphysician-scientist training programpost-docpost-doctoralpost-doctoral traineepre-clinicalpreclinicalprogramsregenerateresearch associatesresponse to injurysocial rolesuccesstranscription factortranscriptional profilingtranscriptometranscriptome sequencingtranscriptomic sequencing
Description preview
Project Summary
The goal of this K08 application is to provide a rigorous 5-year scientific and career development training plan
that will facilitate the transition of Dr. Glynnis Garry from a post-doctoral fellow to a fully independent investigator
as a cardiovascular physician-scientist. Dr. Garry obtained her medical degree from Vanderbilt…
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