grant
Characterization of hematopoietic stem cell (HSC) and progenitor cell aging, identification of candidate age-regulated genes as targets for therapeutic intervention
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAgeAgingAnimalsAttenuatedAutoimmune StatusAutoimmunityAutomobile DrivingAutoregulationBiologic ModelsBiologicalBiological ModelsBloodBlood Precursor CellBlood Reticuloendothelial SystemBreedingCategoriesCell AgingCell BodyCell CompartmentationCell CompartmentationsCell SenescenceCellsCellular AgingCellular SenescenceDNA DamageDNA Damage RepairDNA InjuryDNA MethylationDNA RepairData AnalysesData AnalysisDiseaseDisorderDysmyelopoietic SyndromesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessGenesHSC agingHematopoieticHematopoietic Progenitor CellsHematopoietic stem cellsHistoryHomeostasisHumanInterventionLymphoidMaintenanceMiceMice MammalsModel SystemModern ManMurineMusMyelodysplastic DiseaseMyelodysplastic SyndromesNorwayNorway RatsOrganoidsPathway interactionsPhenotypePhysiological HomeostasisProgenitor CellsRattus norvegicusRecording of previous eventsRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsReplicative SenescenceReproducibilityResearchResearch ResourcesResourcesSmoldering LeukemiaSolidSystemTherapeutic InterventionUnscheduled DNA SynthesisWorkadult progenitoradult stem celladulthoodage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage reversalage specificage specific alterationsage specific changesagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging reversalaging specific alterationsaging specific changesalleviate age relatedalleviate agingalterations with ageameliorating agingattenuateattenuatesbiologicblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcandidate identificationcell typechanges with agecounter age relatedcounter agingcounteract age relatedcounteract agingdata interpretationdrivingepigenetic regulationepigeneticallyexperimentexperimental researchexperimental studyexperimentsfallshematopoietic progenitorhematopoietic stem cell aginghematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhistoriesin vivointerestintervention therapylarge data setslarge datasetsleukemiamouse modelmurine modelmyelodysplasianon-human primatenonhuman primatepathwaypreventpreventingprimitive cellprogenitor agingprogenitor biologyprogenitor cell agingprogenitor cell biologyregeneration potentialregenerative potentialreplicative agingresponserestorationreverse agereverse agingreverse aging effectsreversible agingsexsomatic progenitorsomatic stem cellstem and progenitor biologystem cell agingstem cell biologystem cellstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic target
Description preview
The ESC Unit's focus on "Characterization of hematopoietic stem cell (HSC) and progenitor cell aging, identification of candidate age-regulated genes as targets for therapeutic intervention" has been focused on establishing a solid platform for which all experiments will be built from.
One of the systems the Epigenetics and Stem Cell (ESC)…
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