grant
Characterization of Enterovirus 68 3C Protease For the Development of Robust and Potent Direct-Acting Antiviral Inhibitors
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 15 Dec 2023Deadline 14 Dec 2028
NIHUS FederalResearch GrantFY20250-11 years old3-D3-Dimensional3DActive SitesAcute NasopharyngitisAcute PoliomyelitisAffectAffinityAnti-viral AgentsAntiproteasesAssayBindingBioassayBiological AssayBrain InflammationCase StudyCaspaseCaspase GeneCell-Death ProteaseCessation of lifeChildChild YouthChildren (0-21)ClinicalCocrystallizationCocrystallographyCommon ColdComplexComputational TechniqueConsensusCrystallizationCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesDNA mutationDataDeathDefectDevelopmentDisease OutbreaksDrug DesignDrug TargetingDrug resistanceDrugsEV-68EV-D68EncephalitisEndopeptidase InhibitorsEnterovirusEnterovirus 68Enterovirus D68Enzyme GeneEnzyme InhibitionEnzyme InteractionEnzymesEsteroproteasesFRETFamilyFamily PicornaviridaeFluorescenceFluorescence Resonance Energy TransferFood and Drug AdministrationFutureFörster Resonance Energy TransferGenetic ChangeGenetic defectGenetic mutationGoalsGray Matter of the Spinal CordHand, Foot and Mouth DiseaseHealth Care SystemsHepatitisICE-like proteaseIncidenceInfectionMedicationMolecularMolecular InteractionMutationMyocarditisNeurologicNeurologic DeficitNeurologicalOutbreaksPalsyParalysedPatientsPeptidase InhibitorsPeptidasesPeptide Hydrolase InhibitorsPeptide HydrolasesPeptide Peptidohydrolase InhibitorsPharmaceutical PreparationsPhysiciansPicornaviridaePicornavirusesPlegiaPolioPoliomyelitisPolyproteinsPredispositionProtease AntagonistsProtease GeneProtease InhibitorProteasesProteinase InhibitorsProteinasesProteolytic EnzymesPublic HealthRNA VirusesResearchResistanceRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderScientistSeveritiesSiteSpinal cord grey matter structureStructureSubstrate SpecificitySusceptibilityTestingTrainingUSFDAUnited StatesUnited States Food and Drug AdministrationViralVirusVirus InhibitorsVisualizationWorkacute flaccid myelitisanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbuild resiliencebuild resiliencycardiac inflammationcase reportcystein proteasecystein proteinasecysteine endopeptidasedesigndesigningdevelop resiliencedevelop resiliencydevelopmentaldrug resistantdrug/agentemerging pathogenenhance resilienceenhance resiliencyenzyme substrateexperiencefacilitate resiliencefitnessfunctional groupgenome mutationglobal healthimprove resilienceimprove resiliencyincrease resilienceincrease resiliencyinhibitorinsightkidsnano-molarnanomolarnew pathogennovelnovel pathogenparalysisparalyticpromote resiliencepromote resiliencyresilienceresilience developmentresilientresistance mutationresistance to Drugresistantresistant mutationresistant to Drugrespiratoryscaffoldscaffoldingsmall molecular inhibitorsmall moleculesmall molecule inhibitorstructural biologythree dimensionaltrendviral inhibitoryoungster
Description preview
Project Abstract:
Certain viruses in the picornaviridae family, specifically enterovirus-D68 (EV68), have emerged as global health
concerns over the last decade with severe symptomatic infections with EV68 able to result in long lasting
neurological deficits and death. There are currently no US Food and Drug Administration approved drugs for any…
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