grant
Characterization of alcohol interoceptive effects following predator odor exposure: relevance to PTSD
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 12 Sept 2017Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025Alcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnteriorAttenuatedBedsBehaviorBehavioralCaringCell Communication and SignalingCell SignalingCommon Rat StrainsCorticosteroneDrug TherapyEtOH drinkingEtOH useExposure toFecesFundingGene ExpressionGlutamatesImmobilizationIndividualIndividual DifferencesIntracellular Communication and SignalingL-GlutamateLiteratureMeasuresMental disordersMental health disordersMessenger RNAMetabotropic Glutamate ReceptorsN Methyl D aspartic AcidN methyl D aspartateN-Methyl-D-Aspartate ReceptorsN-Methyl-D-aspartateN-MethylaspartateN-Methylaspartate ReceptorsNMDANMDA Receptor-Ionophore ComplexNMDA ReceptorsNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsNucleus AccumbensOdorsPTSDPathologyPathway interactionsPharmacological TreatmentPharmacotherapyPhenotypePost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPre-Clinical ModelPreclinical ModelsProceduresPsychiatric DiseasePsychiatric DisorderRatRats MammalsRattusReceptor GeneReceptor ProteinRodent ModelSelf AdministeredSelf AdministrationSignal TransductionSignal Transduction SystemsSignalingStressSubgroupSystemSystems DevelopmentTestingTherapeuticTimeTraumaalcohol co-morbidityalcohol comorbidityalcohol effectalcohol ingestionalcohol intakealcohol product usealcohol sensitivityalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeantagonismantagonistattenuateattenuatesbiological signal transductionconditioningdrinkingdrug discriminationdrug interventiondrug treatmentethanol consumptionethanol drinkingethanol effectethanol ingestionethanol intakeethanol product useethanol sensitivityethanol useethanol use disorderexperienceexperimentexperimental researchexperimental studyexperimentsfoxesgenetic approachgenetic strategyglutamatergichigh riskinnovateinnovationinnovativeinterestmRNAmental illnessneurobiologicalneuronalneurophysiologicalneurophysiologyorthopedic freezingpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-trauma stress disorderposttrauma stress disorderpre-clinicalpreclinicalpreventpreventingpsychiatric illnesspsychological disorderreceptorreceptor expressionresponsesensitivity to alcoholsensitivity to ethanolstoolstress reactivitystressortraumatic eventtraumatic neurosis
Description preview
Project Summary
Individuals who suffer from post-traumatic stress disorder (PTSD) are often at higher risk for developing comorbid
alcohol use disorder (AUD). Studying individual differences in response to stress is important as not everyone
who experiences trauma or witnesses a traumatic event develops PTSD. In preclinical models, exposure to the…
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