grant
Characterization of a commensal enteric virus
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 20 Sept 2011Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Abnormal CellAddressAmino Acid SequenceAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoptosisApoptosis InhibitorApoptosis Inhibitor GeneApoptosis PathwayAutocrine SystemsAutophagocytosisAutoregulationAwardBackBasic Fibroblast Growth FactorBasic Fibroblast Growth Factor GeneBindingBiochemistryBiological ChemistryBiological FunctionBiological ProcessBody TissuesCell BodyCell CommunicationCell Communication and SignalingCell CompartmentationCell CompartmentationsCell DeathCell InteractionCell NucleusCell ProtectionCell SignalingCell SurvivalCell ViabilityCell to Cell Communication and SignalingCell-Cell SignalingCell-to-Cell InteractionCellsCharacteristicsChronicCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCytoplasmCytoplasmic GranulesCytoprotectionDNA mutationDataDefectDevelopmentDiseaseDisorderDorsumDysfunctionELISAEnteralEntericEnvironmental FactorEnvironmental Risk FactorEnzyme-Linked Immunosorbent AssayEpithelial CellsEpitheliumExtracellular ProteinExtracellular SpaceFGF-2FGF2FGF2 geneFGFBFibroblast Growth Factor 2Fibroblast Growth Factor 2 GeneFibroblastsFunctional disorderFundingGI commensalGene CombinationsGene DeletionGeneticGenetic ChangeGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic defectGenetic mutationGenetic propensityGranulomatous EnteritisHBGF-2HealthHeparin-Binding Growth Factor 2Heparin-Binding Growth Factor Class IIHomeostasisIFNImmuneImmune responseImmunesIn VitroInfectionInfectious AgentInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInherited PredispositionInherited SusceptibilityInhibition of ApoptosisInjuryIntercellular SpaceInterferonsIntestinalIntestinal DiseasesIntestinal DisorderIntestinesIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLymphatic cellLymphocyteLymphocyticLysosomesMediatingMiceMice MammalsMitochondriaMitochondria RNAMitochondrial RNAModelingMolecular InteractionMurineMusMutant Strains MiceMutationNecrosisNecroticNorovirusNorwalk-like VirusesNucleusNull MouseOrganoidsPaneth CellsPathway interactionsPatientsPhysiological HomeostasisPhysiopathologyPredispositionPredisposition genePrimary Protein StructureProcessProductionProgrammed Cell DeathPropertyProstate Epithelial Cell Growth FactorRNA VirusesRecombinant ProteinsRisk-associated variantSignal TransductionSignal Transduction SystemsSignalingSpecificitySusceptibilitySusceptibility GeneSystemT-CellsT-LymphocyteTeff cellTestingTherapeutic InterventionTissuesViral DiseasesVirusVirus DiseasesWild Type Mouseanti-microbialantimicrobialautocrineautophagybFGFbiological signal transductionbowelbowel inflammationcell typecofactorcommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecytokinecytoprotectivedevelopmentaleffector T celleleocolitisenteric commensalenvironmental riskenzyme linked immunoassayextracellulargastrointestinal commensalgene deletion mutationgene interactiongenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgenome mutationgranulegut commensalgut healthgut inflammationgut microbesgut microbial specieshost responsehuman diseaseimmune system responseimmunoresponseimprovedin vivoinfectious organisminflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinhibition of autophagyinjuriesinjury to the intestinesintercellular communicationintervention therapyintestinal autoinflammationintestinal barrierintestinal commensalintestinal epitheliumintestinal inflammationintestinal injuryintestinal microbesintestinal mucosal barrierintestine diseaseintestine disorderlymph cellmitochondrialmouse mutantmtRNAmutantnecrocytosisnovelparacrinepathophysiologypathwaypredisposing genepreventpreventingprotein sequenceregional enteritisresilienceresilientresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsusceptibility allelesusceptibility locussusceptibility variantthymus derived lymphocyteviral infectionvirus infectionvirus-induced diseasewildtype mouse
Description preview
SUMMARY
Crosstalk between immune cells and the epithelium protects the intestinal barrier from infectious and non-
infectious threats. Elucidating the signals that mediate this cellular crosstalk is necessary to improve our
understanding of diseases associated with barrier dysfunction, such as Crohn's disease (CD), a major type of
inflammatory…
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