grant

Changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for synucleinopathies

Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2025AD related dementiaADRDAcetylationAgeAge MonthsAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmerican Cancer SocietyAreaArtifactsAssayAutopsyBAC cloneBACsBacterial Artificial ChromosomesBasic ResearchBasic ScienceBindingBioassayBiochemicalBiological AssayBiological MarkersBiopsyBody TissuesBrainBrain Nervous SystemCecumCell FractionationChemical FractionationClinicalColonColonoscopyConstipationDA NeuronDataDementia with Lewy BodiesDepositDepositionDetectionDevelopmentDiagnosisDiagnosticDiseaseDisorderDopamine neuronDysautonomia-Orthostatic Hypotension SyndromeDysautonomic Orthostatic HypotensionDysfunctionEncephalonEnteric Nervous SystemEvaluationEventFRACNFosteringFractionationFractionation RadiotherapyFunctional disorderFutureGeneral PopulationGeneral PublicGeneticGenetic predisposing factorGliosisGoalsGuidelinesHumanImageImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodLB dementiaLewy BodiesLewy Body DementiaLewy Body Type Senile DementiaLewy dementiaLewy neuritesLewy-related neuritesLinkMeasuresMedicalMembraneMiceMice MammalsMissionModelingModern ManMolecular InteractionMorphologic artifactsMotorMultiple System AtrophyMultiple System Atrophy SyndromeMultisystem AtrophyMultisystemic AtrophyMurineMusN-terminalNAC precursorNH2-terminalNational Institutes of HealthNerve CellsNerve DegenerationNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuron DegenerationNeuronsNeuroprotectantsNeuroprotective AgentsNeuroprotective DrugsPARK1 proteinPARK4 proteinParalysis AgitansParkinsonParkinson DiseasePathogenesisPathogenicityPathologicPathologyPatientsPhosphorylationPhysiologicPhysiologicalPhysiopathologyPrimary ParkinsonismProgressive Autonomic FailureProtein PhosphorylationPublic HealthREM Behavior DisorderREM Sleep Behavior DisorderRapid Eye Movement Behavior DisorderRapid Eye Movement Sleep Behavior DisorderRecombinantsRectumResearchRiskRisk FactorsRoleSNCASNCA proteinScreening for cancerSeverity of illnessShy-Drager SyndromeShy-Drager Type Idiopathic Orthostatic HypotensionSigmoidSigmoid colonSubstantia NigraSubstantia nigra structureSymptomsSynapsesSynapticSynaptic VesiclesTestingTherapeutic InterventionTissue ExtractsTissuesTranslational ResearchTranslational ScienceUnited States National Institutes of HealthWestern BlottingWestern ImmunoblottingWorka-syna-synucleinagesalpha synucleinalpha synuclein genealphaSP22annual screeningasynbio-markersbiologic markerbiomarkerbrain tissuecohortcompare to controlcomparison controldensitydevelopmentaldisease diagnosisdisease prognosticdisease severitydopaminergic neuronearly biomarkersearly cancer detectionearly detection biomarkersearly detection markersgenetic risk factorhigh riskhuman subjectileumimaginginherited factorinnovateinnovationinnovativeintervention therapymembrane structuremotor behaviormotor symptommouse modelmurine modelnecropsyneural degenerationneurodegenerationneurodegenerativeneurological degenerationneurological diseaseneuronalneuronal degenerationneuropathologicneuropathologicalneuropathologynon A-beta component of AD amyloidnon A4 component of amyloid precursornovelpathophysiologypostmortemprognosticprotein blottingrecommended screeningroutine screeningscreening cancer patientsscreening guidelinesscreening recommendationssocial rolesubcellular fractionationsynapsesynucleinopathytherapeutic targettimelinetranslation researchtranslational investigationα synuclein geneα-synα-synuclein
Sign up free to applyApply link · pipeline · email alerts
— or —

Get email alerts for similar roles

Weekly digest · no password needed · unsubscribe any time

Description preview

PROJECT SUMMARY/ABSTRACT
Aggregation of α-Synuclein (αSyn) in brain Lewy bodies (LB) is a key pathological feature in Parkinson’s dis-
ease (PD) and Alzheimer’s disease related dementias (ADRD) including Lewy body dementia (LBD). The neu-
rodegeneration that leads to PD and LBD precedes diagnosis by up to a decade or more, with constipation
being…

🔒

Full details available on the Agency plan

Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.

Start 7-day free trial — $29.99/mo →

Agency Plan

7-day free trial

Unlock procurement & grants

Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.

$29.99 / month

  • 🔔Email alerts for new matching tenders
  • 🗂️Track tenders in your pipeline
  • 💰Filter by contract value
  • 📥Export results to CSV
  • 📌Save searches with one click
Start 7-day free trial →

Explore more

📍 More grants in UNITED STATES🏷 More NIH opportunities🏷 More US Federal opportunities🏷 More Research Grant opportunities🏢 All nih_reporter opportunities
Changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for synucleinopathies — WEILL MEDICAL COLL | Dev Procure