grant
Centriole and ubiquitin pathway regulation of craniofacial development
Organization NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCHLocation UNITED STATES
NIHUS FederalResearch GrantFY2025APF-1ATP-Dependent Proteolysis Factor 1Animal ModelAnimal Models and Related StudiesBody TissuesCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCentriolesCentrosomeChronic DiseaseChronic IllnessClinicClustered Regularly Interspaced Short Palindromic Repeats interferenceComplementComplement ProteinsCongenital DisordersCoupledCraniofacial AbnormalitiesDNA mutationDefectDevelopmentDiseaseDisorderEarly identificationEventFaceFutureGeneticGenetic ChangeGenetic ModelsGenetic ScreeningGenetic defectGenetic mutationGoalsHMG-20High Mobility Protein 20ImpairmentMaintenanceMolecularMutationOutcomePathway interactionsPatientsProgenitor CellsPublicationsRegulationResearchScientific PublicationStructural Birth DefectStructural Congenital AnomaliesTechnologyTissuesTranslatingUbiquitinchronic disordercomplementationcongenital structural malformationcraniofacialcraniofacial anomaliescraniofacial defectscraniofacial developmentcraniofacial disordercraniofacial malformationcraniofaciesdevelopmentalfacesfacialgenome mutationhuman derived modelhuman derived systemhuman like modelhuman like platformhuman like systemhuman progenitorhuman specific modelhuman specific systemhuman stem cellshuman-based biological modelshuman-based modelhuman-based nonanimal modelshuman-based platformhuman-based researchhuman-based systemhuman-based toolshuman-focused researchin vivoinduced pluripotent stem cells derived from patientsinduced pluripotent stem cells from patientsinsightmodel of animalmouse geneticsnew alternative methodologiesnew alternative methodsnew approach methodologiesnew approach methodsnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-animal methodsnovelnovel alternative methodologiesnovel alternative methodsnovel approach methodologiesnovel approach methodsnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypatient derived human iPSpatient derived human iPSCpatient derived human induced pluripotent stem cellpatient derived iPSpatient derived iPSCpatient derived induced pluripotent cellspatient derived induced pluripotent stem cellspatient-derived pluripotent stem cellsprogenitor cell modelprogenitor modelrepressing CRISPR-dCas9 systemstem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelstem cells
Description preview
Over the past year the Craniofacial Development Unit has made progress in understanding how disruptions in centrioles/centrosomes contribute to impaired craniofacial development resulting in chronic disease and structural birth defects. We have identified early developmental events that precede and drive the emergence of craniofacial…
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