grant
Central mechanisms of glucocorticoid circadian rhythm dysfunction in breast cancer
Organization COLD SPRING HARBOR LABORATORYLocation COLD SPRING HARBOR, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025ACTHACTH-Releasing FactorAcuteAdenohypophysisAdrenal CortexAdrenal GlandsAdrenalsAdrenocorticotropic HormoneAdrenocorticotropinAeroseb-HCAnterior Pituitary GlandAnterior pituitaryArousalAutomobile DrivingBody TissuesBreast CancerBreast Cancer CellBreast Cancer ModelBreast Cancer PatientBreast NeoplasmsBreast Tumor PatientBreast TumorsBreast tumor modelCRF-41CRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalciumCancer InductionCancer PatientCancersCas nuclease technologyCell BodyCellsCetacortCheckpoint inhibitorCircadian RhythmsCirculationClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColorectal CancerCort-DomeCortefCortenemaCorticoliberinCorticosteroneCorticotropinCorticotropin-Releasing FactorCorticotropin-Releasing Factor-41Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone-41CortisolCortisprayCortrilCytotoxic cellDREADDsDataDermacortDevelopmentDexamethasoneDiseaseDisorderDissectionDistalDysfunctionEldecortElectrophysiologyElectrophysiology (science)Excitatory SynapseExhibitsFatigueFeedbackFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderGene ExpressionGeneralized GrowthGenesGeneticGlucocorticoidsGrowthGuide RNAHPA axisHealthHydrocortisoneHydrocortoneHypophysisHypophysis CerebriHypothalamic structureHypothalamusHytoneImageImmuneImmune checkpoint inhibitorImmune mediated therapyImmune responseImmunesImmunityImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologically Directed TherapyImmunotherapyImpairmentInjectionsK lymphocyteKnock-outKnockoutLack of EnergyLifeLinkMalignantMalignant - descriptorMalignant Breast NeoplasmMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the LungMalignant Tumor of the OvaryMalignant neoplasm of lungMalignant neoplasm of ovaryMammary CancerMammary NeoplasmsMediatingMetastatic breast cancerMiceMice MammalsMolecularMurineMusNK CellsNatural Killer CellsNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNutracortNyctohemeral RhythmOrganism-Level ProcessOrganismal ProcessOutcomeOvary CancerPalpableParaventricular Hypothalamic NucleusPars Anterior Pituitary GlandPatientsPeripheralPhasePhenotypePhysiologic ProcessesPhysiological ProcessesPhysiopathologyPituitaryPituitary GlandPituitary Nervous SystemProcessProctocortProductionProteinsPulmonary CancerPulmonary malignant NeoplasmQOLQuality of lifeRNA SeqRNA sequencingRNAseqReportingSliceSolid NeoplasmSolid TumorSpecific qualifier valueSpecifiedSystemTestingTherapeuticTimeTissue BanksTissue CollectionTissue GrowthTissue repositoryTissuesTreatment EfficacyTwenty-Four Hour RhythmWomanWorkadrenal gland cortexanti-canceranti-cancer immunotherapyanticancer immunotherapybreast cancer progressionbreast tumor cellcancer immunotherapycancer progressioncandidate identificationcarcinogenesiscell typecheck point blockadecheck point inhibitioncheckpoint blockadecheckpoint inhibitioncircadiancircadian clockcircadian pacemakercircadian processcircadian rhythmicitycorticotropin releasing hormonedaily biorhythmdata integrationdesigndesigner receptors exclusively activated by designer drugsdesigningdevelopmentaldrivingelectrophysiologicalexperienceexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygRNAhost responsehypothalamichypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisimagingimmune check point blockadeimmune check point inhibitionimmune check point inhibitorimmune checkpoint blockadeimmune checkpoint inhibitionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimmunotherapy for cancerimmunotherapy of cancerimprovedimproved outcomein vivoindividuals with breast cancerintervention efficacylung cancermalignancymalignant breast tumormammary cancer modelmammary tumormammary tumor modelmetastatic breast tumormetastatic mammary cancermetastatic mammary tumormortalitymouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic progressionneural controlneural regulationneuromodulationneuromodulatoryneuronalneuroregulationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachontogenyovarian cancerpalpable diseaseparaventricular nucleuspathophysiologypatients with breast cancerperson with breast cancerpituitary anterior lobepituitary gland anterior lobepre-clinicalpreclinicalresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsuprarenal glandtherapeutic efficacytherapy efficacytooltraffickingtranscriptome sequencingtranscriptomic sequencingtumortumor growthtumor progressionvirtual
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Project Summary
Breast cancer is still the most common malignancy in women worldwide. Despite the incredible advances made
in the past decades towards eliminating breast cancer, nearly all women with metastatic breast cancer will
succumb to the disease. Therefore, we desperately need new and improved approaches towards eliminating
breast cancer.…
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