grant
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment
Organization JOHN D DINGELL VA MEDICAL CENTERLocation DETROIT, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
VANIHUS FederalResearch GrantFY2026AddressApneaArousalBenefits and RisksBreathingCO2Carbon DioxideCarbonic AnhydrideCaringCentral Alveolar HypoventilationCentral ApneaCentral Sleep ApneaCentral Sleep Apnea SyndromeCentral Sleep-Disordered BreathingCentral Sleep-Disordered BreathingsChemoreceptorsChronicClinical ResearchClinical StudyClinical TrialsCombined Modality TherapyCritical PathsCritical PathwaysDataDevicesDiagnosisDrugsDysfunctionFunctional disorderFutureGoalsHeart failureHyperventilationHypocapniaHypoxiaHypoxicIndustryInterventionIntervention StudiesMechanical ventilationMedicationMultimodal TherapyMultimodal TreatmentNasalNasal Passages NoseNerveNoseObstructive Sleep ApneaOndine SyndromeOutcomeOxygen DeficiencyPathogenesisPathway interactionsPatientsPeriodicalsPeripheralPharmaceutical PreparationsPhysiologicPhysiologicalPhysiopathologyPlantsQOLQuality of lifeRecommendationRecurrenceRecurrentReflexReflex actionResolutionRespirationRespiratory AspirationRespiratory InspirationRespiratory System, Nose, Nasal PassagesSleepSleep ApneaSleep Apnea SyndromesSleep HypopneaSleep-Disordered BreathingSyndrome, Sleep Apnea, ObstructiveTestingTherapeuticTherapeutic InterventionTimeTradozoneTrazodoneVeteransVeterans Health AdministrationVeterans Health AffairsWorkadverse consequenceadverse outcomeairflow limitationairflow obstructionairway limitationairway obstructioncardiac failureco-morbidco-morbiditycombination therapycombined modality treatmentcombined treatmentcomorbiditydrug/agenteffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsheart failure and reduced ejection fractionheart failure with reduced ejection fractionhypnoticimprovedimproved outcomeimprovement on sleepindexinginnovateinnovationinnovativeinspirationintervention researchintervention therapyinterventional researchinterventional studyinterventions researchlung volumemechanical respiratory assistmechanically ventilatedmulti-component interventionmulti-faceted interventionmulti-modal interventionmulti-modal therapymulti-modal treatmentmulticomponent interventionmultifaceted interventionmultimodal interventionnovelobstructed airflowobstructed airwaypathophysiologypathwayperiodicperiodicalpositive airway pressurepressureprimary outcomereceptor sensitivityrepurposingresolutionsrespiratoryrespiratory airway obstructionrespiratory mechanismsleep improvementsleep-related breathing disordersobersobrietysupplemental oxygentrait
Description preview
Our objective is to test mechanistic pathways to inform future clinical studies investigating the potential treatment
of central sleep apnea (CSA) in veterans with heart failure and reduced ejection fraction (HF). The long-term
goal is to transform the care of veterans living with these two conditions. We will test two key determinants of…
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